Reduction in Dietary Methionine May Achieve Better Outcomes for Patients with Multiple Sclerosis

Reduction in Dietary Methionine May Achieve Better Outcomes for Patients with Multiple Sclerosis

Publication date: Feb 13, 2020

Reduction in Dietary Methionine May Achieve Better Outcomes for Patients with Multiple Sclerosis Significantly reducing dietary levels of the amino acid methionine could slow the onset and progression of inflammatory and autoimmune disorders, such as multiple sclerosis (MS) in patients with a high-risk.

The study’s findings suggest that patients predisposed to inflammatory and autoimmune disorders such as MS may benefit from reducing methionine intake. -These findings provide further basis for dietary interventions as future treatments for these disorders,” said Russell Jones, PhD, senior study author and program leader of Van Andel Institute’s Metabolic and Nutritional Programming group. During an immune response, T cells flood the affected area to help the body fend off pathogens.

This inflammation is a normal part of an immune response but could cause damage if it lingers, such as the nerve damage that occurs in MS. According to the study authors, restricting methionine in the diet removes the fuel for this overactive inflammatory response without compromising the rest of the immune system. Autoimmune disorders occur when the immune system mistakenly attacks and destroys healthy tissue.

Concepts Keywords
Amino Acid Adverse events numbness
Autoimmune Disorders Inflammatory autoimmune disorders
Brain Amino acids
Cognitive Medical specialties
Flood Immunology
Immune Response Methionine
Immune System Thioethers
Inflammation Autoimmunity
Methionine Nutrition
Methionine Metabolism Immune system
Montreal Multiple sclerosis
Multiple Sclerosis Vitamin B12 deficiency
Muscle Weakness MTRR
Myelin Sheath MS
Nerve Inflammation inflammation
Numbness
Obesity
PhD
Russell Jones
Spinal Cord

Semantics

Type Source Name
disease MESH obesity
disease MESH cognitive decline
drug DRUGBANK Isoxaflutole
disease MESH numbness
disease MESH inflammation
pathway REACTOME Immune System
disease MESH Multiple Sclerosis
drug DRUGBANK Tropicamide
drug DRUGBANK Methionine

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