Regulation of Oligodendrocyte Functions: Targeting Lipid Metabolism and Extracellular Matrix for Myelin Repair.

Publication date: Feb 08, 2020

: Myelin is an essential structure that protects axons, provides metabolic support to neurons and allows fast nerve transmission. Several neurological diseases, such as multiple sclerosis, are characterized by myelin damage, which is responsible of severe functional impairment. Myelin repair requires the timely recruitment of adult oligodendrocyte precursor cells (OPCs) at the lesion sites, their differentiation and maturation into myelinating oligodendrocytes. As a consequence, OPCs undergo profound changes in their morphology, functions, and interactions with other cells and extracellular environment, thus requiring the reorganization of both their lipid metabolism and their membrane composition, which is substantially different compared to other plasma membranes. Despite the growing knowledge in oligodendroglia biology and in the mechanisms involved in OPC-mediated regeneration, the identification of strategies to promote remyelination still remains a challenge. Here, we describe how altered lipid metabolism in oligodendrocytes influences the pathogenesis of demyelination, and we show that several FDA-approved drugs with a previously unknown remyelination potential do act on cholesterol and lipid biosynthetic pathways. Since the interplay between myelin lipids and axons is strictly coordinated by the extracellular matrix (ECM), we also discuss the role of different ECM components, and report the last findings on new ECM-modifiers able to foster endogenous remyelination.

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Marangon, D., Boccazzi, M., Lecca, D., and Fumagalli, M. Regulation of Oligodendrocyte Functions: Targeting Lipid Metabolism and Extracellular Matrix for Myelin Repair. 20197. 2020 J Clin Med (9):2.

Concepts Keywords
Axons Demyelinating disease
Cholesterol Oligodendrocyte
Demyelination Myelin
ECM Remyelination
Endogenous Organ systems
Extracellular Neuroscience
Extracellular Matrix Glial cells
FDA Branches of biology
Interplay Multiple sclerosis
Lesion Pathogenesis demyelination
Lipid Axon
Lipid Metabolism Oligodendrocyte progenitor cell
Lipids Extracellular matrix
Membrane
Morphology
Multiple Sclerosis
Myelin
Nerve
Neurological Diseases
Neurons
Oligodendrocyte
Oligodendrocytes
Oligodendroglia
OPC
Pathogenesis
Plasma

Semantics

Type Source Name
disease MESH multiple sclerosis
disease MESH demyelination
drug DRUGBANK Cholesterol

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