Resting-state brain network topological properties and the correlation with neuropsychological assessment in adolescent narcolepsy.

Publication date: Feb 12, 2020

To evaluate functional connectivity and topological properties of brain networks, and to investigate the association between brain topological properties and neuropsychiatric behaviors in adolescent narcolepsy.

Resting-state functional magnetic resonance imaging and neuropsychological assessment were applied in 26 adolescent narcolepsy patients and 30 healthy controls. Functional magnetic resonance imaging data were analyzed in 3 ways: group independent component analysis and a graph theoretical method were applied to evaluate topological properties within the whole brain. Lastly, network-based statistics was utilized for group comparisons in region-to-region connectivity. The relationship between topological properties and neuropsychiatric behaviors was analyzed with correlation analyses.

In addition to sleepiness, depressive symptoms and impulsivity were detected in adolescent narcolepsy. In adolescent narcolepsy, functional connectivity was decreased between regions of the limbic system and the default mode network, and increased in the visual network. Adolescent narcolepsy patients exhibited disrupted small-world network properties. Regional alterations in the caudate nucleus and posterior cingulate gyrus were associated with subjective sleepiness and regional alterations in the caudate nucleus and inferior occipital gyrus were associated with impulsiveness. Remodeling within the salience network and the default mode network was associated with sleepiness, depressive feelings and impulsive behaviors in narcolepsy.

Alterations in brain connectivity and regional topological properties in narcoleptic adolescents were associated with their sleepiness, depressive feelings and impulsive behaviors.

Xiao, F., Spruyt, K., Lu, C., Zhao, D., Zhang, J., and Han, F. Resting-state brain network topological properties and the correlation with neuropsychological assessment in adolescent narcolepsy. 21018. 2020 Sleep.

Concepts Keywords
Brain Magnetic resonance imaging
Caudate Nucleus Ways
Correlation Visual network
Default Mode Network State brain network
Functional Connectivity Neuroscience
Graph Theoretical Attention
Gyrus Branches of biology
Impulsivity RTT
Limbic System Anxiety
Narcolepsy Medical imaging
Narcoleptic Neuroimaging
Neuropsychiatric Resting state fMRI
Occipital Caudate nucleus
Posterior Cingulate Gyrus Narcolepsy
Sleepiness Default mode network
Topological Properties Posterior cingulate cortex
Magnetic resonance imaging

Semantics

Type Source Name
disease MESH narcolepsy
disease MESH sleepiness
disease MESH depressive symptoms
disease MESH impulsivity
disease MESH visual

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *