Organ-on-a-chip: recent breakthroughs and future prospects.

Publication date: Feb 12, 2020

The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a physiological organ biomimetic system built on a microfluidic chip. Through a combination of cell biology, engineering, and biomaterial technology, the microenvironment of the chip simulates that of the organ in terms of tissue interfaces and mechanical stimulation. This reflects the structural and functional characteristics of human tissue and can predict response to an array of stimuli including drug responses and environmental effects. OOAC has broad applications in precision medicine and biological defense strategies. Here, we introduce the concepts of OOAC and review its application to the construction of physiological models, drug development, and toxicology from the perspective of different organs. We further discuss existing challenges and provide future perspectives for its application.

Open Access PDF

Wu, Q., Liu, J., Wang, X., Feng, L., Wu, J., Zhu, X., Wen, W., and Gong, X. Organ-on-a-chip: recent breakthroughs and future prospects. 06327. 2020 Biomed Eng Online (19):1.

Concepts Keywords
Biomaterial Natural sciences
Biomimetic Drug development
Drug Development Organ-on-a-chip
Engineering Nanotechnology
Microenvironment Biotechnology
Microfluidic Articles
Organ Tissue engineering
Toxicology Microfluidics

Semantics

Type Source Name
disease MESH development
disease MESH separation
drug DRUGBANK Pentaerythritol tetranitrate
pathway REACTOME Reproduction
drug DRUGBANK Flunarizine
drug DRUGBANK Fenamole
drug DRUGBANK Acetate ion
drug DRUGBANK Carbon dioxide
disease MESH visual
disease MESH drug toxicity
disease MESH tumors
drug DRUGBANK Gelatin
drug DRUGBANK Indoleacetic acid
disease MESH hepatitis
drug DRUGBANK Ethanol
drug DRUGBANK Naproxen
disease MESH pulmonary edema
drug DRUGBANK Medical air
drug DRUGBANK Glycolic acid
disease MESH preterm infants
disease MESH respiratory failure
drug DRUGBANK Oxygen
disease MESH asthma
pathway KEGG Asthma
disease MESH renal
disease MESH kidney disease
drug DRUGBANK Troleandomycin
disease MESH dilated cardiomyopathy
disease MESH biopsy
drug DRUGBANK Coenzyme M
drug DRUGBANK Ethionamide
disease MESH drug interactions
disease MESH hypoxia
drug DRUGBANK Trestolone
drug DRUGBANK Stanolone
disease MESH inflammation
drug DRUGBANK Nonoxynol-9
drug DRUGBANK Tretinoin
drug DRUGBANK Tretamine
drug DRUGBANK Polyvinyl alcohol
drug DRUGBANK Ademetionine
drug DRUGBANK Guanosine
disease MESH lung cancer
disease MESH lung inflammation
pathway KEGG Drug metabolism
drug DRUGBANK Carboxyamidotriazole
drug DRUGBANK Alginic acid
disease MESH hypertrophy
drug DRUGBANK Mesenchymal Stem Cells

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