Publication date: Feb 29, 2020
The study published in Nature Genetics details how international collaborators from The Hospital for Sick Children (SickKids) in Canada and research teams from Japan’s Osaka University were able to reverse repeat mutation length in the brains of a mouse model with Huntington’s disease.
In Huntington’s and similar conditions, the more repeat sequences (ie, the greater the repeat mutation length), the more severe the symptoms and the earlier the onset and the faster the progression of the disease.
Since longer expansions over time are directly associated with more severe disease, our findings offer hope for the ability to delay the onset of Huntington’s and slow its progression,” said study principal investigator Dr Christopher Pearson, SickKids Senior Scientist in Genetics & Genome Biology.
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