Paternal age is affected by genetic abnormalities, perinatal complications and mental health of the offspring.

Publication date: Mar 01, 2020

Infertility and fecundity problems concern 10-18% of partners in their reproductive years compromising around one million females and males in Poland. Research and analysis of factors that affect male fertility are limited, especially, regarding the age of the father and determining the age at which quality of semen decreases. Age of the father has greater impact than maternal age, on cases of sporadic autosomal dominant congenital diseases such as Apert, Crouzon, Pfeiffer, Noonan and Costello syndromes, multiple endocrine neoplasia (types 2A and 2B) and achondroplasia. However, there are only a few reports taking paternal advanced age into consideration for pre-mature birth, low Apgar scores or admission to a neonatal intensive care department. Paternal age increases the frequency of congenital diseases such as heart malformations as well as oral, palate and lip cleft. Moreover, mental disorders (autism, schizophrenia, bipolar disorder, low IQ level as well as ADHD) also occur more frequently in advanced father’s age. Advanced paternal age is defined differently in every research. It depends on disorders in offspring we are talking about. Paternal age has an impact on child’s health and development and it is as significant as maternal age, when it comes to reproductive matters.

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Janeczko, D., Holowczuk, M., Orzel, A., Klatka, B., and Semczuk, A. Paternal age is affected by genetic abnormalities, perinatal complications and mental health of the offspring. 15355. 2020 Biomed Rep (12):3.

Concepts Keywords
Achondroplasia Paternal age effect
ADHD Advanced maternal age
Apgar Scores Genetic disorder
Autism Achondroplasia
Autosomal Dominant Autism
Bipolar Disorder Medical specialties
Congenital Health
Department RTT
Fecundity Disorders
Fertility Mental disorders
Frequency Disorder
Genetic Multiple endocrine neoplasia
Infertility Infertility
Lip Birth defect
Maternal Age Medicine
Mental Disorders
Multiple Endocrine Neoplasia
Neonatal Intensive Care


Type Source Name
disease MESH abnormalities
disease MESH complications
disease MESH Infertility
disease MESH congenital
disease MESH syndromes
disease MESH multiple endocrine neoplasia
disease MESH achondroplasia
disease MESH mental disorders
disease MESH autism
disease MESH schizophrenia
disease MESH bipolar disorder
disease MESH development
disease MESH congenital abnormalities

Original Article

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