Cortical excitation-inhibition ratio mediates the effect of pre-attentive auditory processing deficits on interpersonal difficulties.

Publication date: Mar 02, 2020

Several lines of evidence identify aberrant excitatory-inhibitory neural processes across autism and schizophrenia spectrum disorders, particularly within the psychosocial domain. Such neural processes include increased excitatory glutamate and reduced inhibitory GABA concentrations, which may affect auditory pre-attentive processing as indexed by the mismatch negativity (MMN); thus, an excitation-inhibition imbalance might lead to aberrant MMN, which might in turn drive the relationship between the MMN and psychosocial difficulties. This research has the potential to enhance the neurochemical understanding of the relationship between electrophysiology (MMN) and behavioural/clinical measures (psychosocial difficulties). Thirty-eight adults (18 male, 18-40?years) completed the Schizotypal Personality Questionnaire (SPQ) and Autism-Spectrum Quotient (AQ). Glutamate and GABA concentrations in bilateral superior temporal cortex (STC) were quantified using proton magnetic resonance spectroscopy (1H-MRS) while auditory MMN to a duration deviant was measured with magnetoencephalography. Spearman correlations probed the relationships between STC glutamate/GABA ratios, MMN amplitude and latency, and AQ and SPQ dimensions. Mediation effects of glutamate/GABA ratios on the relationship between MMN and AQ-SPQ dimensions were probed using causal mediation analysis. Only SPQ-interpersonal and AQ-communication were significantly correlated with right hemisphere glutamate/GABA ratios and MMN latency (ps?

Ford, T.C., Woods, W., Enticott, P.G., and Crewther, D.P. Cortical excitation-inhibition ratio mediates the effect of pre-attentive auditory processing deficits on interpersonal difficulties. 15365. 2020 Prog Neuropsychopharmacol Biol Psychiatry (98):

Concepts Keywords
Amplitude Neuroscience
Auditory Branches of biology
Autism Drugs
Electrophysiology Glutamate
Excitatory Neurotransmitters
GABA Amino acids
Glutamate Electroencephalography
Hemisphere Mismatch negativity
Latency Gamma-Aminobutyric acid
Magnetoencephalography MMN
Mismatch Negativity Inhibitory postsynaptic potential
Proton Glutamic acid
Psychosocial Spectroscopy
Resonance
Schizophrenia
Spectroscopy
Spectrum
Superior Temporal Cortex

Semantics

Type Source Name
disease MESH autism
disease MESH schizophrenia
drug DRUGBANK gamma-Aminobutyric acid

Original Article

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