Neocortical morphometry in Huntington’s disease: Indication of the coexistence of abnormal neurodevelopmental and neurodegenerative processes.

Neocortical morphometry in Huntington’s disease: Indication of the coexistence of abnormal neurodevelopmental and neurodegenerative processes.

Publication date: Mar 03, 2020

Here, we investigated cortical sulcal depth, related to degenerative process, as well as cortical sulcal length, related to developmental process, in early-stage HD and age-matched healthy controls.

This morphometric analysis revealed significant differences in the HD participants compared with the healthy controls bilaterally in the central and intra-parietal sulcus, but also in the left intermediate frontal sulcus and calcarine fissure.

Conversely, the sulcal morphometry also revealed a crucial difference in the imprint of the Sylvian fissure that could not be related to loss of grey matter volume: an absence of asymmetry in the length of this fissure in HD.

Concepts Keywords
Atrophy Degenerative disorder
Autosomal Dominant Autosomal dominant disorder
Cortical Foetal timing disease
Degenerative Disorder Sulci
Elsevier Anatomy
Fissure Branches of biology
Genetic Medical Subject Headings
Grey Matter Neuroanatomy
Huntington Neuroscience
Imprint Sulcus
Interplay Cerebral cortex
Morphometric Lateral sulcus
Morphometry Calcarine sulcus
Neocortex Fissure
Neurodegenerative
Neurodevelopment
Neurodevelopmental
Parietal
Primary Visual Cortex
Striatum
Sulcal
Sulci
Sulcus
Sylvian Fissure
Vivo

Semantics

Type Source Name
disease MESH development
disease MESH atrophy

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *