Publication date: Mar 17, 2020
Over the last couple of decades researchers have started implicating inflammation as playing a role in a number of conditions not traditionally thought of as autoimmune diseases, particularly in reference to the brain.
In this new study, published in the journal Brain, researchers scanned the brains of 31 subjects with three very different types of frontotemporal dementia (FTD).
These different kinds of dementia all present different clinical and pathological signs, however, the aggregation of specific toxic proteins in damaged areas of the brain is one unifying factor.
“We predicted the link between inflammation in the brain and the build-up of damaging proteins, but even we were surprised by how tightly these two problems mapped on to each other,” says Thomas Cope, one of the authors on the new study.
A secondary study examining 12 post-mortem brains found similar patterns between toxic protein build-up and neuroinflammation.
-The illnesses are in other ways very different from each other, but we have found a role for inflammation in all of them,” explains James Rowe, one of the researchers working on the study.