Cambridge study adds evidence linking brain inflammation with dementia

Cambridge study adds evidence linking brain inflammation with dementia

Publication date: Mar 17, 2020

Over the last couple of decades researchers have started implicating inflammation as playing a role in a number of conditions not traditionally thought of as autoimmune diseases, particularly in reference to the brain.

In this new study, published in the journal Brain, researchers scanned the brains of 31 subjects with three very different types of frontotemporal dementia (FTD).

These different kinds of dementia all present different clinical and pathological signs, however, the aggregation of specific toxic proteins in damaged areas of the brain is one unifying factor.

“We predicted the link between inflammation in the brain and the build-up of damaging proteins, but even we were surprised by how tightly these two problems mapped on to each other,” says Thomas Cope, one of the authors on the new study.

A secondary study examining 12 post-mortem brains found similar patterns between toxic protein build-up and neuroinflammation.

-The illnesses are in other ways very different from each other, but we have found a role for inflammation in all of them,” explains James Rowe, one of the researchers working on the study.

Concepts Keywords
Alzheimer Neurodegeneration
Arthritis Alzheimer’s disease
Autoimmune Disease Dementia
Autoimmune Diseases Neuroinflammation
Brain RTT
Brain Inflammation Learning disabilities
Cambridge Cognitive disorders
Cytotoxicity Neurology
Dementia Psychiatric diagnosis
Frontotemporal Dementia Branches of biology
Huntington Organ systems
Immune System Nervous system
Inflammation Classically autoimmune disease
Microglia Link inflammation
Misfolded Proteins Strong relationship inflammation
Neurodegeneration Common neurodegenerative diseases
Neurodegenerative Diseases Neurodegeneration dementia inflammation
Parkinson Brain inflammation dementia
Pathogen Tomography
Pathogenicity
PET Scan
Plasticity
Positron Emission Tomography
Post Mortem
Suicidal Thoughts
The Note

Semantics

Type Source Name
disease MESH disease progression
disease MESH frontotemporal dementia
disease MESH Depression
disease MESH autoimmune disease
disease MESH arthritis
disease MESH inflammation
pathway REACTOME Neurodegenerative Diseases
disease MESH neurodegenerative diseases
disease MESH brain inflammation
disease MESH dementia

Original Article

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