Publication date: Mar 16, 2020
This will be a single site pilot study. 20 subjects with EPP, defined as medical record documentation of the onset of clinically significant psychotic symptoms within the past 10 years, will be enrolled. Prior to randomization subjects will undergo fMRI during CC task (Stroop Color-Word paradigm) and resting-state paradigms. This baseline scan will also include a high-resolution structural sequence for neuronavigation purposes. Then, on two separate days, each occurring one-week apart, subjects will receive one session of excitatory (20 Hz) rTMS targeting the LDLPFC and one session targeting the LSPC. The order of stimulation sites will be randomized and counter-balanced. Immediately following each session, subjects will undergo repeat fMRI during CC and RS paradigms. Investigators will also examine the effect of rTMS on CC performance.
|disease||MESH||loss of consciousness|
|disease||MESH||drug use disorder|