Interactions of Fronto-Parietal High Frequency rTMS on Anterior Cingulate Cortex Activation in Schizophrenia

Interactions of Fronto-Parietal High Frequency rTMS on Anterior Cingulate Cortex Activation in Schizophrenia

Publication date: Mar 16, 2020

This will be a single site pilot study. 20 subjects with EPP, defined as medical record documentation of the onset of clinically significant psychotic symptoms within the past 10 years, will be enrolled. Prior to randomization subjects will undergo fMRI during CC task (Stroop Color-Word paradigm) and resting-state paradigms. This baseline scan will also include a high-resolution structural sequence for neuronavigation purposes. Then, on two separate days, each occurring one-week apart, subjects will receive one session of excitatory (20 Hz) rTMS targeting the LDLPFC and one session targeting the LSPC. The order of stimulation sites will be randomized and counter-balanced. Immediately following each session, subjects will undergo repeat fMRI during CC and RS paradigms. Investigators will also examine the effect of rTMS on CC performance.

Concepts Keywords
ACC Neurotechnology
Alcohol Neuroimaging
Antipsychotic Electrotherapy
Antipsychotic Medication Magnetic resonance imaging
Brain Psychopathology
Breast Feeding Branches of biology
Caffeine Psychiatry
Clinical Trial Neuroscience
Clinical Trials TENS
Clozapine Cochlear implants
Cochlear Implants Electroconvulsive therapy
Comorbidities Exacerbation illness
Consciousness Interventional Schizophrenia
Crisis Management Seizures
DSM Alcohol drug disorder
Electroconvulsive Therapy Connectivity schizophrenia
Emergency Room Duration illness
Epilepsy Significant unmet schizophrenia
EPP Chronic populations
Excitatory Transcranial magnetic stimulation
Febrile Seizures Schizophrenia
FMRI Psychosis
Fronto Antipsychotic
Functional Connectivity Magnetic resonance imaging
Head Trauma MRI
Hz
Idiopathic
Implanted Pacemaker
Indiana
Informed Consent
Mini
MRI
Neurological Illness
Nicotine
Paradigm
Pharmacological
Psychotic
Randomization
RTMS
Schizophrenia
Seizure
Seizure Disorder
Suicidal Ideation
Suicide
Syndrome
TENS
Treatment Modality
Vagal
Ventriculoperitoneal Shunt

Semantics

Type Source Name
disease MESH febrile seizures
disease MESH diagnosis
disease MESH emergency
disease MESH Schizophrenia
disease MESH epilepsy
disease MESH loss of consciousness
disease MESH post-concussive syndrome
disease MESH Contraindications
drug DRUGBANK Clozapine
disease MESH suicidal ideation
disease MESH suicide
drug DRUGBANK Ethanol
disease MESH drug use disorder
drug DRUGBANK Nicotine
drug DRUGBANK Caffeine

Original Article

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