What are Glial Cells?

What are Glial Cells?

Publication date: Mar 18, 2020

However, scientists are now increasingly recognizing the pivotal role glial cells play in brain function and development.

Glial cells are smaller than neurons but are greater in number than nerve cells in the brain.

The important CNS glial cells are astrocytes, microglia, oligodendrocytes, radial glial cells, and ependymal cells.

The radial glial progenitor cells are multipurpose cells involved in many areas of brain developments and are precursor cells for generating oligodendrocytes, astrocytes, and neurons.

A number of research studies are ongoing to understand the role of glial cells in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease.

Studies on transgenic mice that express a mutant gene associated with one of the diseases have demonstrated that glial cells play a pivotal role in disease pathogenesis.

A study by Pochard et al. explored the role of enteric glial cells in inflammatory bowel disorders such as Crohn’s disease and ulcerative colitis.

However, further research is ongoing to characterize the role of enteric glial cells in gut dysfunction.

For example, in bipolar disorder, schizophrenia, and major depressive disorders, glial cells such as astrocytes, oligodendrocytes, and microglia are affected.

Concepts Keywords
Alcohol Apoptosis
ALS Potassium spatial buffering
Amyotrophic Lateral Sclerosis Glial scar
Apoptosis Microglia
Astrocytes Schwann cell
Autonomic Nervous System Oligodendrocyte
Axon Astrocyte
Axons Radial glial cell
BDNF Myelin
Bipolar Disorder Neuroscience
Blood Glial cells
Blood Flow Branches of biology
Bowel Major depressive disorders
Brain Glial neurodegenerative diseases
Brain Imaging ALS
Central Nervous System Mutant diseases
Cerebrospinal Fluid Neurodegenerative diseases
Chronic Diseases Pain
Cognitive Cytokines injury
Crescent Cytokines injury site
Cytokines Chemical
Cytoplasm Myelination neurons satellite
Defense Mechanisms
Dendrites
Ependymal
Ependymal Cells
Epithelial
FASD
Ganglia
Gastrointestinal System
GFAP
Glial
Glial Cells
Histopathology
Homeostasis
IL 1
Inclusion Bodies
Interleukin
Ion
Medial Prefrontal Cortex
Microglia
Microscopy
Modulation
Morphology
Multiple System Atrophy
Mutant
Myelin
Myelin Sheath
Myelination
Nerve
Nervous System
Neurodegenerative Diseases
Neurons
Neurotropic
Nuclei
Oligodendrocytes
Oxygenation
Pain
Pathogenesis
Pathology
Pathophysiology
Peripheral Nervous System
Phagocytosis
Phenotypes
Pregnancy
Psychiatric Disorders
Psychopharmacology
Psychotropic Drugs
Radial Glial Cells
Retina
Satellite
Schizophrenia
Schwann Cells
Spinal Cord
Star
Superoxide Dismutase
Synapse
Synaptic
Transgenic
Ulcerative Colitis
Ventricles
Vivo

Semantics

Type Source Name
pathway KEGG Apoptosis
disease MESH fetal alcohol spectrum disorders
pathway REACTOME Release
disease MESH multiple system atrophy
drug DRUGBANK Ethanol
disease MESH pathology
disease MESH amyotrophic lateral sclerosis
disease MESH neurodegenerative diseases
disease MESH chronic diseases
disease MESH major depressive disorders
disease MESH schizophrenia
disease MESH psychiatric disorders
disease MESH bipolar disorder
drug DRUGBANK Interleukin-10
disease MESH ulcerative colitis
disease MESH development

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