Association of cognitive activities of daily living (ADL) function and nonmotor burden in nondemented Parkinson’s disease patients.

Publication date: Mar 19, 2020

In Parkinson’s disease (PD), nonmotor symptoms (NMS) considerably influence disease progression and cognitive decline. Depression, anxiety, sleep disturbances, and hallucinations (DASH), may indicate a risk for dementia (PDD). Mild impairments in activities of daily living (ADL) caused by cognitive dysfunction are also present in the prodromal stage of PDD. The association of both factors has been sparsely investigated. Aim was to evaluate these specific NMS in a large nondemented PD cohort and their co-occurrence with cognitive dysfunction and ADL impairments.

Data of 226 PD patients was analyzed. Using corresponding items, two DASH scores were constructed from the NMS-Scale and Parkinson’s disease Questionnaire (PDQ-39). Correlations between DASH scores and PDD risk factors were examined. PD patients with mild cognitive impairment (PD-MCI) were additionally split into patients with low and high DASH burden, the latter group additionally stratified by presence of cognitive-driven ADL impairment.

DASH-NMS scores differed significantly between PD-MCI and cognitively normal (PD-CN) patients (p = .04), while the DASH-PDQ did not (p = .73). The only significant predictor of the DASH-NMS score was cognitive-driven ADL (p = .01). PD-MCI patients with a high DASH burden and more cognitive ADL impairment presented with worse global cognition than patients with a low burden (p = .045).

Our results show that the DASH-NMS is superior to the DASH-PDQ score, related to the severity of cognitive impairment, and strongly influenced by cognitive-driven ADL impairment. Presence of DASH symptoms and cognitive-ADL in PD-MCI patients may define a risk group for PDD conversion. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

Becker, S., B”aumer, A., Maetzler, W., Nussbaum, S., Tkaczynska, Z., Sulzer, P., Timmers, M., Van Nueten, L., Salvadore, G., Brockmann, K., Streffer, J., Berg, D., and , Liepelt-Scarfone. Association of cognitive activities of daily living (ADL) function and nonmotor burden in nondemented Parkinson’s disease patients. 24410. 2020 Neuropsychology.

Concepts Keywords
Aim Cognitive dysfunction
Anxiety Cognitive disorders
Cognition Psychiatric diagnosis
Cognitive Learning disabilities
Cognitive Dysfunction Psychiatry
Cognitive Impairment RTT
Cohort Aging-associated diseases
DASH Cognition
Dementia Dementia
Hallucinations Mild cognitive impairment
Mild Cognitive Impairment
Prodromal Stage
Sleep Disturbances


Type Source Name
disease MESH disease progression
disease MESH cognitive decline
disease MESH Depression
disease MESH anxiety
disease MESH sleep
disease MESH hallucinations
disease MESH dementia
disease MESH risk factors

Original Article

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