Comparison of Analgesic Effect and Prognosis of Butorphanol and Fentanyl in Patients With Mechanical Ventilation

Comparison of Analgesic Effect and Prognosis of Butorphanol and Fentanyl in Patients With Mechanical Ventilation

Publication date: Mar 20, 2020

ICU patients often in a strong stress environment. Various invasive procedures such as wound dressing change, sputum suction,Pull out the thoracic duct etc. At the same time, the diseases and environmental factors caused patients anxiety, pain, delirium and even a series of pathophysiological changes which harm life and safety. Fentanyl is an analgesic that acts on central ? receptors, clinical practice had found that fentanyl could exert analgesic effects, while it maybe affect patients’ hemodynamics, breathing, and nervous system, which caused hypotension, bradycardia, respiratory depression, delirium and other adverse drug reactions. These reactions prolonged the mechanical ventilation time and duration time of patients in hospital, which impact the treatment effect and prognosis of patients. Butorphanol tartrate is a new type of opioid receptor agonist and antagonist, which can stimulate the ? receptor, and also certain stimulated and antagonised effects on the ? receptor. It can be used for analgesia and sedation in patients of ICU. Previous studies shown that butorphanol can inhibit the inflammatory response and effect myocardial protective. The analgesic effect of butorphanol were equivalent to fentanyl in patients of ICU, and the incidence of nausea and vomiting in participants with butorphanol less than fentanyl. Therefore, the investigators speculate that the analgesia of butorphanol in ICU patients may unexpected effects. However, butorphanol and fentanyl on the analgesic effect and prognosis of patients with mechanical ventilation in ICU are lacking currently, and the investigators no corresponding multi-center clinical study at home and abroad. The research compare to the analgesic effect of butorphanol and fentanyl in critically ill patients with mechanical ventilation. Effects of butorphanol and fentanyl on mechanical ventilation duration, sedation depth, duration time of patients in hospital, complications and mortality in patients with mechanical ventilation. To analyze the high-risk factors affecting the prognosis of patients with mechanical ventilation in ICU. Found more treatment measures for analgesia of patients with mechanical ventilation in ICU.

Concepts Keywords
Adverse Drug Reactions Mechanical ventilation
Allergy Catheter
Analgesia Invasive procedures
Analgesic Anxiety pain delirium
Antagonist Nerve injury
Anxiety Pain
ASA Vomiting
BMI Butorphanol
Bradycardia Fentanyl
Brain RTT
Butorphanol Synthetic opioids
Carbon Euphoriants
Catheter Analgesics
Chronic Pain Medicine
Clinical Trial Intensive care medicine
CRO Drugs
Delirium Medical specialties
Epidural Carbon copy
Fentanyl
Hemodynamics
Hospital
Hypotension
Incidence
Informed Consent
Jiangsu
Lactation
Mechanical Ventilation
Morphine
Mortality
Nausea
Nerve Injury
Nervous System
Opioid Receptor Agonist
Opioids
Pain
Pathophysiological
Pregnancy
Prognosis
Receptor
Receptors
Recorder
Recording
Respiratory Depression
SAS
Sedation
Spinal Cord
Sputum
Statistical Test
Statistician
Stress
Tartrate
Thoracic Duct
Vital Signs
Vomiting
Wound Dressing

Semantics

Type Source Name
disease MESH adverse drug reactions
disease MESH respiratory depression
disease MESH bradycardia
disease MESH hypotension
disease MESH delirium
disease MESH anxiety
drug DRUGBANK Fentanyl
drug DRUGBANK Butorphanol
disease MESH critically ill
disease MESH complications
disease MESH risk factors
disease MESH allergy
disease MESH chronic pain
drug DRUGBANK Morphine
drug DRUGBANK Acetylsalicylic acid
disease MESH death

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