The role of chemokines and chemokine receptors in multiple sclerosis.

Publication date: Mar 17, 2020

Multiple sclerosis (MS) is a chronic inflammatory disease that is characterized by leukocyte infiltration and subsequent axonal damage, demyelinating inflammation, and formation of sclerosing plaques in brain tissue. The results of various studies in patients indicate that autoimmunity and inflammation make an important impact on the pathogenesis of MS. Chemokines are key mediators of inflammation development and cell migration, mediating various immune cell responses, including chemotaxis and immune activation, and are important in immunity and inflammation, therefore we focus on chemokines and their receptors in multiple sclerosis. In this article, we summarize the study of the role of prominent chemokines and their receptors in MS patients and MS animal modelsand discuss their potential significance in inflammatory injury and repair of MS. We have also summarized the progress in the treatment of multiple sclerosis antagonists in recent years with chemokine receptors as targets.

Open Access PDF

Cui, L.Y., Chu, S.F., and Chen, N.H. The role of chemokines and chemokine receptors in multiple sclerosis. 20503. 2020 Int Immunopharmacol (83):

Concepts Keywords
Autoimmunity Inflammation
Brain CCL8
Chemokine Chemotaxis
Chemokines Signal transduction
Chemotaxis Immunology
Immunity Chemokine
Inflammation Cell biology
Leukocyte Cytokines
Multiple Sclerosis Branches of biology
Pathogenesis Multiple sclerosis
Receptors

Semantics

Type Source Name
disease MESH multiple sclerosis
disease MESH inflammation
disease MESH autoimmunity
disease MESH development
drug DRUGBANK Coenzyme M
drug DRUGBANK (S)-Des-Me-Ampa
disease MESH sclerosis
disease MESH relapsing remitting multiple sclerosis
disease MESH primary progressive multiple sclerosis
disease MESH demyelination
drug DRUGBANK Trestolone
disease MESH encephalomyelitis
disease MESH paralysis
disease MESH Hepatitis
disease MESH diphtheria
drug DRUGBANK Chlorpromazine
disease MESH infection
disease MESH autoimmune diseases
drug DRUGBANK Flunarizine
drug DRUGBANK L-Cysteine
disease MESH abnormalities
drug DRUGBANK Angiotensin II
drug DRUGBANK Somatostatin
pathway KEGG ABC transporters
disease MESH depression
drug DRUGBANK Methylprednisolone
disease MESH histopathology
drug DRUGBANK Esomeprazole
drug DRUGBANK Cycloserine
disease MESH acute disease
disease MESH relapse
disease MESH men
drug DRUGBANK Glutamic Acid
drug DRUGBANK L-Leucine
drug DRUGBANK L-Arginine
drug DRUGBANK Proline
drug DRUGBANK Glycine
drug DRUGBANK Methionine
disease MESH viral infections
disease MESH hyperplasia
drug DRUGBANK Natalizumab
drug DRUGBANK Amino acids
drug DRUGBANK Pyridoxal Phosphate
drug DRUGBANK Alendronic acid
drug DRUGBANK INCB3284
disease MESH asthma
pathway KEGG Asthma
drug DRUGBANK Maraviroc
disease MESH death
disease MESH scars
disease MESH autoimmune encephalitis
disease MESH atherosclerosis
drug DRUGBANK Adenosine 5′-phosphosulfate
disease MESH neurodegenerative diseases
disease MESH CNS disease
drug DRUGBANK Imidazole
drug DRUGBANK Angelica archangelica root
disease MESH Mult
drug DRUGBANK Isoxaflutole
drug DRUGBANK Filgrastim
drug DRUGBANK Ranitidine
disease MESH experimental autoimmune encephalomyelitis
drug DRUGBANK BK-MDA
drug DRUGBANK Sulfasalazine
drug DRUGBANK ATP
disease MESH Arthritis
drug DRUGBANK Guanosine
drug DRUGBANK Adenosine
drug DRUGBANK Rosiglitazone
disease MESH rheumatoid arthritis
pathway KEGG Rheumatoid arthritis
drug DRUGBANK Rituximab
disease MESH osteoarthritis
disease MESH diagnosis

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