Autoimmunity in Acute Myocarditis: How Immunopathogenesis Steers New Directions for Diagnosis and Treatment.

Publication date: Mar 20, 2020

Over the last decade, myocarditis has been increasingly recognized as common cause of sudden cardiac death in young adults and heart failure overall. The purpose of this review is to discuss hypothesis of development of non-infectious myocarditis, to provide a description of the immunopathogenesis and the most common mechanisms of autoimmunity in myocarditis, and to provide an update on therapeutic options.

A new entity of myocarditis is immune checkpoint inhibitor (ICI) induced myocarditis. ICIs are used in advanced cancer to “disinhibit” the immune system and make it more aggressive in fighting cancer. This novel drug class has doubled life expectancy in metastatic melanoma and significantly increased progression free survival in advanced non-small-cell lung cancer, but comes with a risk of autoimmune diseases such as myocarditis resulting from an overly aggressive immune system. Myocarditis is an inflammatory disease of the heart with major public health impact. Thorough understanding of its immunopathogenesis is crucial for accurate diagnosis and effective treatment.

Open Access PDF

Bruestle, K., Hackner, K., Kreye, G., and Heidecker, B. Autoimmunity in Acute Myocarditis: How Immunopathogenesis Steers New Directions for Diagnosis and Treatment. 26196. 2020 Curr Cardiol Rep (22):5.

Concepts Keywords
Autoimmune Diseases Immunology
Autoimmunity Heart diseases
Cancer Cancer treatments
Heart Failure Clinical medicine
ICI Medicine
Immune Checkpoint Inhibitor Medical specialties
Immune System Expectancy metastatic melanoma
Melanoma Non infectious myocarditis
Myocarditis Immune system
Sudden Cardiac Death Myocarditis
RTT
Checkpoint inhibitor
Autoimmunity

Semantics

Type Source Name
disease MESH Autoimmunity
disease MESH Myocarditis
disease MESH Diagnosis
disease MESH sudden cardiac death
disease MESH heart failure
disease MESH development
disease MESH cancer
disease MESH melanoma
pathway KEGG Melanoma
disease MESH lung cancer
disease MESH autoimmune diseases

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