Long-term survival after surgical treatment followed by adjuvant systemic therapy for primary duodenal melanoma.

Publication date: Mar 20, 2020

Primary mucosal malignant melanomas of the gastrointestinal tract are rare tumors associated to poor prognosis. Primary duodenal involvement by pigmented lesions is even more uncommon, and only a few reports exist in the literature. We report the case of a patient with large primary duodenal melanoma that presented with upper intestinal obstruction and bleeding that was submitted to urgent pancreaticoduodenectomy followed by adjuvant systemic therapy with an oral alkylating agent (temozolomide) plus intravenous cisplatin. The patient presents no signs of recurrence 3 years after the surgery. We consider that radical surgical resection followed by systemic therapy is a safe and effective treatment strategy option for primary mucosal gastrointestinal melanomas.

Surjan, R.C.T., do Prado Silveira, S., Dos Santos, E.S., and de Meirelles, L.R. Long-term survival after surgical treatment followed by adjuvant systemic therapy for primary duodenal melanoma. 26195. 2020 Clin J Gastroenterol.

Concepts Keywords
Adjuvant Malignant melanomas
Bleeding Upper intestinal obstruction
Cisplatin Surgery
Duodenal Surgical treatment
Gastrointestinal Health sciences
Gastrointestinal Tract Medical specialties
Intestinal Obstruction Melanoma
Intravenous RTT
Malignant Cancer
Melanoma Pancreaticoduodenectomy
Melanomas Therapy
Prognosis Uveal melanoma
Surgical Resection
Systemic Therapy

Semantics

Type Source Name
disease MESH melanoma
pathway KEGG Melanoma
disease MESH tumors
disease MESH intestinal obstruction
disease MESH bleeding
drug DRUGBANK Temozolomide
drug DRUGBANK Cisplatin
disease MESH recurrence
disease MESH Duodenal neoplasms

Original Article

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