Precision medicine – networks to the rescue.

Publication date: Mar 18, 2020

Genetic variants are often not predictive of the phenotypic outcome. Individuals carrying the same pathogenic variant, associated with Mendelian or complex disease, can manifest to different extents, from severe-to-mild to no disease. Improving the accuracy of predicted clinical manifestations of genetic variants has emerged as one of the biggest challenges in precision medicine, which can only be addressed by understanding the mechanisms underlying genotype-phenotype relationships. Efforts to understand the molecular basis of these relationships have identified complex systems of interacting biomolecules that underlie cellular function. Here, we review recent advances in how modeling cellular systems as networks of interacting proteins has fueled identification of disease-associated processes, delineation of underlying molecular mechanisms, and prediction of the pathogenicity of variants. This review is intended to be inspiring for clinicians, geneticists, and network biologists alike who aim to jointly advance our understanding of human disease and accelerate progress toward precision medicine.

Yadav, A., Vidal, M., and Luck, K. Precision medicine – networks to the rescue. 06546. 2020 Curr Opin Biotechnol (63):

Concepts Keywords
Biomolecules Mendelian complex disease
Complex Systems Branches of biology
Genetic Systems biology
Genotype Evidence-based medicine
Mendelian Precision medicine
Pathogenic Actin
Pathogenicity Genotype
Phenotype
Phenotypic
Precision Medicine

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