Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases.

Publication date: Mar 18, 2020

: Vitamin D is widely known for its roles in the promotion of apoptosis and differentiation, with simultaneous inhibition of proliferation, inflammation, angiogenesis, invasion, and metastasis. Modern literature lacks complete information on polymorphisms in CYP27B1, the only enzyme capable of vitamin D activation. This review presents gathered data that relate to genetic variants in CYP27B1 gene in correlation to multiple diseases, mostly concerning colorectal, prostate, breast, lung, and pancreatic cancers, as well as on other pathologies, such as non-Hodgkin’s lymphoma, oral lichen planus, or multiple sclerosis.

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Latacz, M., Snarska, J., Kostyra, E., Fiedorowicz, E., Savelkoul, H.F., Grzybowski, R., and Cie’sli’nska, A. Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases. 20509. 2020 Nutrients (12):3.

Concepts Keywords
Angiogenesis Single nucleotide polymorphism
Apoptosis Apoptosis
Breast Alpha
Correlation Clinical medicine
Enzyme Health
Genetic Branches of biology
Inflammation Prostate cancer
Lichen Planus 25-Hydroxyvitamin D3 1-alpha-hydroxylase
Lung RTT
Lymphoma Tumors
Malignant Multiple sclerosis
Multiple Sclerosis
Single Nucleotide Polymorphisms


Type Source Name
disease MESH growth
disease MESH estrogen
disease MESH B cell lymphoma
drug DRUGBANK Myricetin
disease MESH carcinogenesis
drug DRUGBANK Cholecalciferol
disease MESH malignant melanoma
disease MESH lymphoma
disease MESH sarcoidosis
disease MESH granulomas
disease MESH hypercalcemia
drug DRUGBANK Calcium
drug DRUGBANK Calcitriol
pathway KEGG Prostate cancer
disease MESH prostate cancer
pathway KEGG Breast cancer
disease MESH breast cancer
pathway KEGG Colorectal cancer
disease MESH colorectal cancer
disease MESH multiple sclerosis
disease MESH oral lichen planus
disease MESH pancreatic cancers
disease MESH metastasis
disease MESH inflammation
pathway KEGG Apoptosis
drug DRUGBANK Vitamin D
disease MESH Chronic Diseases
disease MESH Tumors
drug DRUGBANK Calcifediol
disease MESH Vitamin deficiency
disease MESH cardiovascular disease
disease MESH autoimmune disease
drug DRUGBANK Amino acids
drug DRUGBANK Parathyroid hormone
drug DRUGBANK Cyclic Adenosine Monophosphate
disease MESH renal
drug DRUGBANK Aspartame
disease MESH rickets
drug DRUGBANK Spinosad
disease MESH men
disease MESH suffering
drug DRUGBANK Progesterone
disease MESH arthralgia
disease MESH lung cancer
disease MESH smokers
disease MESH diagnosis
disease MESH thyroid cancer
pathway KEGG Thyroid cancer
drug DRUGBANK Methyprylon
disease MESH hepatitis
disease MESH hepatocellular carcinoma
pathway KEGG Hepatocellular carcinoma
disease MESH chronic hepatitis
disease MESH risk factors
disease MESH congestive heart failure
disease MESH hypertension
disease MESH encephalomyelitis
disease MESH pathology
disease MESH point mutations
disease MESH colon cancer
pathway KEGG Pancreatic cancer
disease MESH Liver cancer
disease MESH oral cancer
drug DRUGBANK Adenine
drug DRUGBANK Thymine
drug DRUGBANK Guanine
drug DRUGBANK Efavirenz
disease MESH myeloid leukemia
drug DRUGBANK Vorinostat
disease MESH rectal cancer
disease MESH bile
disease MESH carcinoma
disease MESH lifestyle
drug DRUGBANK Copper
disease MESH recurrence
disease MESH death
disease MESH Aging
drug DRUGBANK Nitrazepam
disease MESH premature mortality
disease MESH papillary thyroid carcinoma
disease MESH alcoholic cirrhosis
disease MESH chronic hepatitis C
disease MESH non Hodgkin lymphoma
drug DRUGBANK Natural alpha interferon
disease MESH Mult
disease MESH experimental autoimmune encephalomyelitis
disease MESH Genetic disorders
drug DRUGBANK (S)-Des-Me-Ampa


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