The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer.

Publication date: Mar 18, 2020

MicroRNAs (miRNAs) are small noncoding RNAs playing a fundamental role in the regulation of gene expression. Evidence accumulating in the past decades indicate that they are capable of simultaneously modulating diverse signaling pathways involved in a variety of pathophysiological processes. In the present review, we provide a comprehensive overview of the function of a highly conserved group of miRNAs, the miR-181 family, both in physiological as well as in pathological conditions. We summarize a large body of studies highlighting a role for this miRNA family in the regulation of key biological processes such as embryonic development, cell proliferation, apoptosis, autophagy, mitochondrial function, and immune response. Importantly, members of this family have been involved in many pathological processes underlying the most common neurodegenerative disorders as well as different solid tumors and hematological malignancies. The relevance of this miRNA family in the pathogenesis of these disorders and their possible influence on the severity of their manifestations will be discussed. A better understanding of the miR-181 family in pathological conditions may open new therapeutic avenues for devasting disorders such as neurodegenerative diseases and cancer.

Open Access PDF

Indrieri, A., Carrella, S., Carotenuto, P., Banfi, S., and Franco, B. The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer. 24435. 2020 Int J Mol Sci (21):6.

Concepts Keywords
Apoptosis Non-coding RNA
Autophagy Molecular genetics
Cancer MicroRNA
Embryonic Development Gene expression
Hematological Malignancies Branches of biology
Immune Response RNA
MiRNA MiR-324-5p
Mitochondrial MIR489
Neurodegeneration Apoptosis
Neurodegenerative Diseases
Neurodegenerative Disorders


Type Source Name
disease MESH Development
disease MESH Cancer
pathway KEGG Apoptosis
pathway KEGG Autophagy
disease MESH pathological processes
disease MESH neurodegenerative disorders
disease MESH hematological malignancies
drug DRUGBANK Tropicamide


Original Article

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