Neuroprotective effect of regular swimming exercise on calretinin-positive striatal neurons of Parkinsonian rats.

Publication date: Mar 21, 2020

In Parkinson’s disease (PD), physical therapy is one of the mainstays of supportive treatment modalities. This study focused on the neuroprotective effect of regular exercise on striatal calretinin positive interneurons in a rat model of PD. 6-hydroxydopamine (6-OHDA) was injected unilaterally into the medial forebrain bundle of Wistar rats. 6-OHDA lesioned (Parkinsonian) and unlesioned (control) rats were divided into sedentary and exercise groups. Exercise groups had daily swimming sessions for 30 min for 6 weeks. After 6-OHDA injections, an apomorphine-induced rotation test was performed (0.05 mg/kg, subcutaneous) at the 3rd and 6th weeks. At the end of the 6th week, brains were removed following transcardiac perfusion. The brain sections were stained immunohistochemically for tyrosine hydroxylase and calretinin reactivity. The number of rotations was significantly lower in Parkinsonian exercise group compared to Parkinsonian sedentary group at the 6th week (p?=?0.024) and there was significant difference between Parkisonian sedentary groups at the 3rd and 6th weeks (p?

Concepts Keywords
Anat Physical therapy
Apomorphine Branches of biology
Brain Organ systems
Immunohistochemically Medicine
Interneurons Neurotoxins
Neurons Calretinin
Neuroprotective Parkinson’s disease
Parkinson Oxidopamine
Parkinsonian Medial forebrain bundle
Perfusion Interneuron
Physical Therapy Exercise
Rotation Apomorphine
Sci Hydroxydopamine
Tyrosine Hydroxylase
Wistar Rats


Type Source Name
drug DRUGBANK Apomorphine
drug DRUGBANK L-Tyrosine

Original Article

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