Connexins in oligodendrocytes and astrocytes: possible factors for demyelination in multiple sclerosis.

Connexins in oligodendrocytes and astrocytes: possible factors for demyelination in multiple sclerosis.

Publication date: Mar 19, 2020

Increasing evidences support that glial connexins are involved in the demyelination pathology of multiple sclerosis (MS), a chronic inflammatory demyelinating disorder. Here, we review the data from patients with MS and animal models of MS that implicate connexins in demyelination. Connexins expressed in oligodendrocytes and astrocytes show diverse changes at the different phases of MS. Loss of oligodendrocyte or astrocyte connexins contributes to demyelination and exaggerates the pathology of MS. Channel-dependent and -independent connexins are involved in the pathology of demyelination, which is related with myelin integrity, metabolic homeostasis, the brain-blood barrier, the immune cell infiltration, and the inflammatory response. A comprehensive understanding of connexin function in demyelination may provide new therapeutic targets for MS.

Xia, C.Y., Xu, J.K., Pan, C.H., Lian, W.W., Yan, Y., Ma, B.Z., He, J., and Zhang, W.K. Connexins in oligodendrocytes and astrocytes: possible factors for demyelination in multiple sclerosis. 20518. 2020 Neurochem Int.

Concepts Keywords
Astrocyte Demyelination
Astrocytes Pathology demyelination
Blood MS
Brain Branches of biology
Connexin Glial cells
Connexins Proteins
Demyelination Myelin
Glial Connexin
Homeostasis Oligodendrocyte
Inflammatory Response Demyelinating disease
Multiple Sclerosis Astrocyte
Myelin Multiple sclerosis
Oligodendrocyte
Oligodendrocytes
Pathology

Semantics

Type Source Name
disease MESH demyelination
disease MESH multiple sclerosis
disease MESH pathology

Original Article

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