Conversion of diffusely abnormal white matter to focal lesions is linked to progression in secondary progressive multiple sclerosis.

Conversion of diffusely abnormal white matter to focal lesions is linked to progression in secondary progressive multiple sclerosis.

Publication date: Mar 23, 2020

Diffusely abnormal white matter (DAWM) regions are observed in magnetic resonance images of secondary progressive multiple sclerosis (SPMS) patients. However, their role in clinical progression is still not established.

To characterize the longitudinal volumetric and intensity evolution of DAWM and focal white matter lesions (FWML) and assess their associations with clinical outcomes and progression in SPMS.

Data include 589 SPMS participants followed up for 3?years (3951 time points). FWML and DAWM were automatically segmented. Screening DAWM volumes that transformed into FWML at the last visit (DAWM-to-FWML) and normalized T1-weighted intensities (indicating severity of damage) in those voxels were calculated.

FWML volume increased and DAWM volume decreased with an increase in disease duration (p?

Dadar, M., Narayanan, S., Arnold, D.L., Collins, D.L., and Maranzano, J. Conversion of diffusely abnormal white matter to focal lesions is linked to progression in secondary progressive multiple sclerosis. 20521. 2020 Mult Scler.

Concepts Keywords
Evolution Biology
Magnetic Resonance Images Medicine
Multiple Sclerosis Spms
Normalized Multiple sclerosis
Progressive
Voxels
White Matter

Semantics

Type Source Name
disease MESH secondary progressive multiple sclerosis

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