Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism.

Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism.

Publication date: Mar 19, 2020

Short-chain fatty acids are processed from indigestible dietary fibers by gut bacteria and have immunomodulatory properties. Here, we investigate propionic acid (PA) in multiple sclerosis (MS), an autoimmune and neurodegenerative disease. Serum and feces of subjects with MS exhibited significantly reduced PA amounts compared with controls, particularly after the first relapse. In a proof-of-concept study, we supplemented PA to therapy-naive MS patients and as an add-on to MS immunotherapy. After 2 weeks of PA intake, we observed a significant and sustained increase of functionally competent regulatory T (Treg) cells, whereas Th1 and Th17 cells decreased significantly. Post-hoc analyses revealed a reduced annual relapse rate, disability stabilization, and reduced brain atrophy after 3 years of PA intake. Functional microbiome analysis revealed increased expression of Treg-cell-inducing genes in the intestine after PA intake. Furthermore, PA normalized Treg cell mitochondrial function and morphology in MS. Our findings suggest that PA can serve as a potent immunomodulatory supplement to MS drugs.

Duscha, A., Gisevius, B., Hirschberg, S., Yissachar, N., Stangl, G.I., Eilers, E., , Bader, Haase, S., Kaisler, J., David, C., Schneider, R., Troisi, R., Zent, D., Hegelmaier, T., Dokalis, N., Gerstein, S., Del Mare-Roumani, S., Amidror, S., Staszewski, O., Poschmann, G., St”uhler, K., Hirche, F., Balogh, A., Kempa, S., Tr”ager, P., Zaiss, M.M., Holm, J.B., Massa, M.G., Nielsen, H.B., Faissner, A., Lukas, C., Gatermann, S.G., Scholz, M., Przuntek, H., Prinz, M., Forslund, S.K., Winklhofer, K.F., M”uller, D.N., Linker, R.A., Gold, R., and Haghikia, A. Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism. 20520. 2020 Cell (180):6.

Concepts Keywords
Atrophy MS
Autoimmune Immunotherapy
Bacteria T cells
Brain Branches of biology
Disability Health
Fatty Acids Regulatory T cell
Feces Medicine
Immunomodulatory Dietary fiber
Immunotherapy Immunotherapy
Intestine
Microbiome
Mitochondrial
Morphology
Multiple Sclerosis
Neurodegenerative Disease
Normalized
Propionic Acid
Relapse
Th1
Th17
Treg
Treg Cells

Semantics

Type Source Name
drug DRUGBANK Propanoic acid
disease MESH Multiple Sclerosis
pathway REACTOME Fatty acids
disease MESH neurodegenerative disease
disease MESH relapse
drug DRUGBANK Acetylsalicylic acid
disease MESH autoimmune diseases

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