Publication date: Mar 23, 2020
Located on chromosome locus 5p15.33, telomerase reverse transcriptase (TERT or hTERT) encodes the catalytic subunit of telomerase which permits lengthening and preservation of telomeres following mitosis. Mutations in TERT promoter (TERT-p) upregulate expression of TERT, allowing survival of malignant cells and tumor progression in wide variety of malignancies including melanoma. The objective of this review is to examine the roles of TERT and TERT-p in the pathogenesis, diagnosis, and prognostication of cutaneous melanoma.
All studies of TERT or TERT-p in cutaneous melanocytic neoplasms with the following inclusion criteria were reviewed: publication date between 2010-2019, English language, and series of ?3 cases were reviewed for evidence supporting the role of TERT in pathogenesis, diagnosis, and prognosis prognosis. Studies with
Motaparthi, K., Kim, J., Andea, A.A., Missall, T.A., Novoa, R.A., Vidal, C.I., Fung, M.A., and Emanuel, P.O. TERT and TERT promoter in melanocytic neoplasms: current concepts in pathogenesis, diagnosis, and prognosis. 26207. 2020 J Cutan Pathol.