CXCL-10: a new candidate for melanoma therapy?

CXCL-10: a new candidate for melanoma therapy?

Publication date: Mar 23, 2020

Melanoma is a malignancy that stems from melanocytes and is defined as the most dangerous skin malignancy in terms of metastasis and mortality rates. CXC motif chemokine 10 (CXCL10), also known as interferon gamma-induced protein-10 (IP-10), is a small cytokine-like protein secreted by a wide variety of cell types. CXCL10 is a ligand of the CXC chemokine receptor-3 (CXCR3) and is predominantly expressed by T helper cells (Th cells), cytotoxic T lymphocytes (CTLs), dendritic cells, macrophages, natural killer cells (NKs), as well as some epithelial and cancer cells. Similar to other chemokines, CXCL10 plays a role in immunomodulation, inflammation, hematopoiesis, chemotaxis and leukocyte trafficking.

Recent studies indicate that the CXCL10/CXCR3 axis may act as a double-edged sword in terms of pro- and anti-cancer activities in a variety of tissues and cells, especially in melanoma cells and their microenvironments. Most of these activities arise from the CXCR3 splice variants CXCR3-A, CXCR3-B and CXCR3-Alt. In this review, we discuss the pro- and anti-cancer properties of CXCL10 in various types of tissues and cells, particularly melanoma cells, including its potential as a therapeutic target.

Bagheri, H., Pourhanifeh, M.H., Derakhshan, M., Mahjoubin-Tehran, M., Ghasemi, F., Mousavi, S., Rafiei, R., Abbaszadeh-Goudarzi, K., Mirzaei, H.R., and Mirzaei, H. CXCL-10: a new candidate for melanoma therapy? 26210. 2020 Cell Oncol (Dordr).

Concepts Keywords
Cancer Melanoma therapy
Chemokine Melanoma therapy Melanoma
Chemokines Immunomodulation inflammation
Chemotaxis Branches of biology
Cytokine Cytokines
Cytotoxic CXCR3
Dendritic Cells CXCL10
Epithelial Cells CXC chemokine receptors
Hematopoiesis XCR1
Immunomodulation Melanoma
Inflammation CXCL9
Interferon Gamma CXCL11
Natural Killer
Splice Variants


Type Source Name
disease MESH melanoma
pathway KEGG Melanoma
disease MESH malignancy
disease MESH metastasis
disease MESH inflammation


Original Article

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