Publication date: Mar 25, 2020
Credit: CC0 Public Domain A human genomics study led by two Yale Department of Psychiatry researchers identified specific genetic regions that link opioid exposure and dependence to neuropsychiatric traits like risk-taking behaviors, alcohol abuse, and depression.
The study, published in Molecular Psychiatry, also reported that gene variants associated with opioid dependence are linked to muscle injuries, supporting a potential genetic connection between opioid abuse and management of muscle pain.
He pointed out that “human studies such as this one are a way forward-we now understand the genetics and biology of opioid use disorder, as it occurs in actual humans who either are opioid dependent, have used opioids at some point, or have never used opioids at all, a little better. “
Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium, Molecular Psychiatry (2020).