Genomics study helps researchers better understand opioid epidemic

Genomics study helps researchers better understand opioid epidemic

Publication date: Mar 25, 2020

Credit: CC0 Public Domain A human genomics study led by two Yale Department of Psychiatry researchers identified specific genetic regions that link opioid exposure and dependence to neuropsychiatric traits like risk-taking behaviors, alcohol abuse, and depression.

The study, published in Molecular Psychiatry, also reported that gene variants associated with opioid dependence are linked to muscle injuries, supporting a potential genetic connection between opioid abuse and management of muscle pain.

He pointed out that “human studies such as this one are a way forward-we now understand the genetics and biology of opioid use disorder, as it occurs in actual humans who either are opioid dependent, have used opioids at some point, or have never used opioids at all, a little better. “

Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium, Molecular Psychiatry (2020).

Concepts Keywords
Alcohol Abuse Addiction
Alzheimer Drug overdose
Autism Psychoactive drugs
Bipolar Disorder Medicine
CC0 Medical emergencies
Depression Substance dependence
Drug Overdose Opioid use disorder
Fair Dealing RTT
Genetic Psychiatry
Genome Psychiatric diagnosis
Healthcare Muscle pain
Illicit Drugs Muscle injuries
Muscle Healthcare
Muscle Pain Opioid disorder
Opioid Addiction
Opioid Dependence
Opioid Epidemic


Type Source Name
drug DRUGBANK Tropicamide
disease MESH alcohol abuse
disease MESH depression
disease MESH opioid dependence
disease MESH death
disease MESH autism
disease MESH bipolar disorder
disease MESH schizophrenia


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