Publication date: Mar 24, 2020
Presented By: Dario Alessi, FRS FMedSci FRSE
Speaker Biography: Dario’s research focuses on unravelling the roles of poorly characterised components which regulate protein phosphorylation or ubiquitylation pathways that are linked to human disease. Dario, obtained a BSc (1988) and PhD (1991) from the University of Birmingham, United Kingdom.
Webinar: Keynote Presentation: Interplay between LRRK2 protein kinase and Rab GTPases in Parkinson’s disease
Webinar Abstract: I will discuss the identification and characterization of a novel PPM family phosphatase member that counteracts LRRK2 signalling by dephosphorylating Rab proteins. I will present data that indicates that the LRRK2 parlog termed LRRK1 also functions as a Rab kinase. Finally, I will discuss what is known about how LRRK2 regulates ciliogenesis, the endosomal-lysosome system, and immune responses and how this might be linked to Parkinson?s disease.
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