Keynote Presentation: Interplay between LRRK2 protein kinase and Rab GTPases in Parkinson’s disease

Keynote Presentation: Interplay between LRRK2 protein kinase and Rab GTPases in Parkinson’s disease

Publication date: Mar 24, 2020

Presented By: Dario Alessi, FRS FMedSci FRSE

Speaker Biography: Dario’s research focuses on unravelling the roles of poorly characterised components which regulate protein phosphorylation or ubiquitylation pathways that are linked to human disease. Dario, obtained a BSc (1988) and PhD (1991) from the University of Birmingham, United Kingdom.

Webinar: Keynote Presentation: Interplay between LRRK2 protein kinase and Rab GTPases in Parkinson’s disease

Webinar Abstract: I will discuss the identification and characterization of a novel PPM family phosphatase member that counteracts LRRK2 signalling by dephosphorylating Rab proteins. I will present data that indicates that the LRRK2 parlog termed LRRK1 also functions as a Rab kinase. Finally, I will discuss what is known about how LRRK2 regulates ciliogenesis, the endosomal-lysosome system, and immune responses and how this might be linked to Parkinson?s disease.

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Concepts Keywords
Birmingham World Wide Web
BSc Rab
Ciliogenesis Pinterest
Dephosphorylating LRRK2
Endosomal Neuroscience
Facebook
FMedSci
FRS
GTPases
Instagram
Interplay
Kinase
LinkedIn
Lysosome
Neuroscience
Parkinson
PhD
Phosphatase
Phosphorylation
Pinterest
PPM
Rab
Rab Proteins
SnapChat
Ubiquitylation
United Kingdom
Webinar
YouTube

Semantics

Type Source Name
pathway KEGG Lysosome
drug DRUGBANK Coenzyme M

Original Article

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