Lithium treatment in the era of personalized medicine.

Lithium treatment in the era of personalized medicine.

Publication date: Mar 24, 2020

In 1949, an Australian psychiatrist, John Cade, reported on the antimanic efficacy of lithium carbonate, which is regarded as an introduction of lithium into contemporary psychiatry. Since the 1960s, lithium has been a precursor of mood stabilizers and has become first-choice drug for the prevention of affective episodes in mood disorders. For nearly four decades, lithium has also been used for the augmentation of antidepressant drugs in treatment-resistant depression. The knowledge of clinical and biological factors connected with the capability of long-term lithium treatment to prevent manic and depressive recurrences makes an important element of the personalized medicine of mood disorders. Excellent prophylactic lithium responders can be characterized by distinct mood episodes, with full remissions between them, the absence of other psychiatric morbidity, and the family history of bipolar illness. In recent years, many other clinical and biological factors connected with such a response have been identified, helping to select the best candidates for lithium prophylaxis. The antisuicidal effect of lithium during its long-term administration has been demonstrated and should also be taken into account as the element of personalized medicine for the pharmacological prophylaxis of patients with mood disorders. Several studies pertaining to personalized medicine were also dedicated to lithium treatment of acute mood episodes. Lithium still has a value in the treatment of mania and bipolar depression. However, it seems that the more important indication would be the augmentation of antidepressant drugs in treatment-resistant depression. The factors connected with the efficacy of lithium in these conditions are reviewed.

Rybakowski, J.K. Lithium treatment in the era of personalized medicine. 06564. 2020 Drug Dev Res.

Concepts Keywords
Antidepressant Treatment-resistant depression
Bipolar Depression Bipolar disorder
Bipolar Illness Antidepressant
Lithium Mania
Lithium Carbonate Lithium
Mania Mood stabilizers
Manic Depressive Mood disorders
Mood Disorders Psychiatric diagnosis
Mood Stabilizers RTT
Morbidity Chemistry
Personalized Medicine Psychiatry
Pharmacological Depression
Prophylactic Illness
Prophylaxis
Psychiatrist
Psychiatry
Treatment Resistant Depression

Semantics

Type Source Name
drug DRUGBANK Lithium carbonate
disease MESH mood disorders
disease MESH depression
disease MESH recurrences
disease MESH mania

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