Influence of psychosocial stress on activation in human brain regions: moderation by the 5-HTTLPR genetic locus.

Publication date: Mar 16, 2020

Variants of the serotonin transporter linked polymorphic region (5-HTTLPR) of the serotonin transporter gene SLC6A4 have been related with the onset of depression, anxiety, and other mental disorders. Homozygotes for the short 5-HTTLPR variant, referred to as the SS genotype, have greater cortisol responses to experimentally induced psychosocial stress. In the current study, we used functional magnetic resonance imaging (fMRI) to compare regional brain activations across 5-HTTLPR genotypes in subjects performing the Montreal Imaging Stress Task (MIST). Subjects with an SS genotype had significant greater increases in cortisol concentrations after the task than subjects with at least one long 5-HTTLPR allele. Additionally, relative to L carriers, the SS group had greater activation in the dorsomedial prefrontal cortex(dmPFC), dorsal anterior cingulate cortex, anterior insula.

Sun, X., Li, C., Zhong, X., Dong, D., Ming, Q., Gao, Y., Xiong, G., Cheng, C., Zhao, H., Wang, X., and Yao, S. Influence of psychosocial stress on activation in human brain regions: moderation by the 5-HTTLPR genetic locus. 21346. 2020 Physiol Behav.

Concepts Keywords
Allele Relative carriers
Anterior Cingulate Cortex Branches of biology
Anterior Insula Neuroscience
Anxiety Mood disorders
Brain Serotonin transporter
Cortisol Solute carrier family
Depression 5-HTTLPR
Dorsal Major depressive disorder
FMRI Cortisol
Genetic Locus Magnetic resonance
Genotype Stress
Genotypes Magnetic resonance imaging
Mental Disorders Genotype
Montreal
Polymorphic
Prefrontal
Psychosocial
Serotonin Transporter
SLC6A4

Semantics

Type Source Name
drug DRUGBANK Serotonin
disease MESH depression
disease MESH anxiety
disease MESH mental disorders
drug DRUGBANK Hydrocortisone

Original Article

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