Three Types of Nodal Melanocytic Nevi in Sentinel Lymph Nodes of Patients With Melanoma: Pitfalls, Immunohistochemistry, and a Review of the Literature.

Publication date: Apr 07, 2020

The presence or absence of metastasis in sentinel lymph nodes often drives melanoma staging, prognosis, and treatment. However, distinguishing between metastatic melanoma cells and clusters of benign melanocytic nevus cells is not always straightforward. When morphologic hematoxylin and eosin interpretation alone is not sufficient, additional hematoxylin and eosin sections and immunohistochemical (IHC) studies may be beneficial. This review and small cases series of 3 diagnostically challenging melanocytic sentinel lymph node cases highlights the IHC approach to evaluate intraparenchymal nodal melanocytic nevi, coexistent metastatic melanoma with adjacent melanocytic nevi cells, and nodal blue nevi. In challenging cases, cytological morphology of the melanocytes, location within the lymph node, and IHC studies may assist in diagnosis. If these tools yield conflicting results, expert opinion is recommended.

Concepts Keywords
Cytological Metastasis
Eosin Melanocytic nevus
Hematoxylin Blue nevus
Immunohistochemical Sentinel lymph node
Immunohistochemistry RTT
Lymph Node Cancer
Melanocytes Oncology
Melanocytic Nevi Melanoma
Melanoma Medical specialties
Metastasis Organ systems
Morphologic Medicine
Sentinel Lymph Node
Sentinel Lymph Nodes


Type Source Name
disease MESH diagnosis
disease MESH blue nevi
disease MESH metastasis
pathway KEGG Melanoma
disease MESH Melanoma
disease MESH Melanocytic Nevi

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *