Publication date: Apr 23, 2020
A new study finds there are increased amounts of an unmodified structural protein, called tubulin, in lipid rafts, fatty sections of a cell membrane, compared with non-depressed individuals.
Gsa moved out of the lipid rafts after treatment with antidepressants or after using a drug inhibitor for histone deacetylase 6 (HDAC-6) — an enzyme that removes modifications from tubulin — suggesting a role of tubulin in depression as well.
The data suggest that diminished tubulin acetylation may be essential in harnessing Gsa to lipid rafts during depression.
|drug||DRUGBANK||Sodium lauryl sulfate|