The Biology Of Depression – Similarities In Suicide And Other Brains

The Biology Of Depression – Similarities In Suicide And Other Brains

Publication date: Apr 23, 2020

A new study finds there are increased amounts of an unmodified structural protein, called tubulin, in lipid rafts, fatty sections of a cell membrane, compared with non-depressed individuals.

Gsa moved out of the lipid rafts after treatment with antidepressants or after using a drug inhibitor for histone deacetylase 6 (HDAC-6) — an enzyme that removes modifications from tubulin — suggesting a role of tubulin in depression as well.

The data suggest that diminished tubulin acetylation may be essential in harnessing Gsa to lipid rafts during depression.

Concepts Keywords
Acetyl Antibodies
Acetylated Alpha
Acetylation Antidepressant
Antibodies Histone deacetylase
Antidepressants Major depressive disorder
Brain Tubulin
Depression Acetylation
Enzyme Posttranslational modification
HDAC Proteins
Histone Deacetylase Cytoskeleton
Inhibitor Depression
Lipid Raft Branches of biology
Lipid Rafts
Membrane
Neurotransmitters
Nitrocellulose
Post Mortem
Postmortem
Prefrontal Cortex
Protein
Psychology
Scatter Plots
SDS PAGE
Serotonin
Signaling Molecule
Subgroup
Suicide
Tubulin

Semantics

Type Source Name
disease MESH Depression
disease MESH Suicide
drug DRUGBANK Serotonin
disease MESH diagnosis
pathway REACTOME Acetylation
drug DRUGBANK Sodium lauryl sulfate

Original Article

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