Affective temperaments (TEMPS-A) in panic disorder and healthy probands: Genetic modulation by 5-HTT variation.

Affective temperaments (TEMPS-A) in panic disorder and healthy probands: Genetic modulation by 5-HTT variation.

Publication date: Jan 31, 2020

Objectives: Temperamental traits as ascertained by the Temperament Evaluation of Memphis, Pisa, Paris and San Diego Auto-Questionnaire (TEMPS-A) have been suggested as promising intermediate phenotypes of mental disorders. In anxiety disorders, however, TEMPS scales and their genetic underpinnings are still understudied.Methods: TEMPS-A scores in 109 patients with panic disorder (PD) were compared to a sample of 536 healthy probands. All participants were genotyped for serotonin transporter gene variation (5-HTTLPR/rs25531).Results: PD patients displayed significantly increased scores on the dysthymic, cyclothymic, irritable and anxious subscales, and lower scores on the hyperthymic subscale, respectively (all ps

Concepts Keywords
Alleles Panic disorder
Anxiety Disorders Branches of biology
Cyclothymic Neuroscience
Dysthymic Human behavior
Genetic Personality
Genotype Depression
Memphis Mood disorders
Mental Disorders Serotonin transporter
Modulation 5-HTTLPR
Neurobiological Dysthymia
Panic Disorder Temperament
Paris Anxiety
Phenotypes Genotype
Pisa
San Diego
Serotonin
Serotonin Transporter

Semantics

Type Source Name
disease MESH panic disorder
disease MESH mental disorders
disease MESH anxiety disorders
drug DRUGBANK Serotonin

Original Article

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