[Dynamic inflammatory response in a critically ill COVID-19 patient treated with corticosteroids].

[Dynamic inflammatory response in a critically ill COVID-19 patient treated with corticosteroids].

Publication date: May 25, 2020

To investigate the effect of corticosteroids therapy on the inflammatory response in a critically ill coronavirus disease 2019 (COVID-19) patient.

A 55-year old female patient with critical ill COVID-19 was admitted in Taizhou Hospital on January 19, 2020. The patient was treated with methylprednisolone 80 mg on the 2nd day after admission. Thereafter, the dose was adjusted in a timely manner and the therapy lasted for 13 days. The peripheral lymphocyte subsets (CD3T, CD4 T, CD8 T, NK cells, B cells), as well as serum levels of lymphocyte factors (IL-2, IL-4, IL-6, IL-10, TNF-?, IFN-?) were dynamically monitored.

On D1 of admission, the numbers of peripheral blood CD3 T, CD4 T, CD8 T, and NK cells were significantly lower than the normal range. With the improvement of the disease, the numbers of CD3 T, CD8 T and CD4 T cells gradually recovered and showed a linear growth trend (linear fitting equation: Y=18.59X+109.4, P

Concepts Keywords
Blood CD4
CD3 Lymphocyte
CD4 T helper cell
CD8 T cells
Coronavirus Immune system
Corticosteroids Immunology
Lymphocyte Medicine
Methylprednisolone Branches of biology
Serum Medical specialties
Taizhou Methylprednisolone
TNF Lymphocyte-variant hypereosinophilia
Zhejiang

Semantics

Type Source Name
disease MESH critically ill
drug DRUGBANK Methylprednisolone
drug DRUGBANK Binetrakin
drug DRUGBANK Interleukin-10
disease MESH growth
disease MESH Coronavirus Infections
disease MESH Pneumonia Viral

Original Article

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