Graphene-Based Strategies in Liquid Biopsy and in Viral Diseases Diagnosis.

Graphene-Based Strategies in Liquid Biopsy and in Viral Diseases Diagnosis.

Publication date: May 26, 2020

Graphene-based materials are intriguing nanomaterials with applications ranging from nanotechnology-related devices to drug delivery systems and biosensing. Multifunctional graphene platforms were proposed for the detection of several typical biomarkers (i.e., circulating tumor cells, exosomes, circulating nucleic acids, etc.) in liquid biopsy, and numerous methods, including optical, electrochemical, surface-enhanced Raman scattering (SERS), etc., have been developed for their detection. Due to the massive advancements in biology, material chemistry, and analytical technology, it is necessary to review the progress in this field from both medical and chemical sides. Liquid biopsy is considered a revolutionary technique that is opening unexpected perspectives in the early diagnosis and, in therapy monitoring, severe diseases, including cancer, metabolic syndrome, autoimmune, and neurodegenerative disorders. Although nanotechnology based on graphene has been poorly applied for the rapid diagnosis of viral diseases, the extraordinary properties of graphene (i.e., high electronic conductivity, large specific area, and surface functionalization) can be also exploited for the diagnosis of emerging viral diseases, such as the coronavirus disease 2019 (COVID-19). This review aimed to provide a comprehensive and in-depth summarization of the contribution of graphene-based nanomaterials in liquid biopsy, discussing the remaining challenges and the future trend; moreover, the paper gave the first look at the potentiality of graphene in COVID-19 diagnosis.

Concepts Keywords
Analytical Technology Chemical
Autoimmune Viral diseases
Basel Tumor
Biomarkers Autoimmune neurodegenerative disorders
Biopsy Cancer metabolic syndrome
Biosensing Drug delivery systems
Cancer Medicine
Conductivity Clinical medicine
Coronavirus Branches of biology
Drug Delivery Emerging technologies
Electrochemical Biopsy
Exosomes Liquid biopsy
Graphene Exosome
Material Chemistry Nanomaterials
Metabolic Syndrome Circulating tumor cell
Nanomaterials Biomarker
Nanotechnology Drug delivery
Neurodegenerative Disorders
Nucleic Acids


Type Source Name
disease MESH Biopsy
disease MESH Viral Diseases
disease MESH Diagnosis
disease MESH circulating tumor cells
disease MESH cancer
disease MESH metabolic syndrome
disease MESH neurodegenerative disorders

Original Article

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