Neuroimaging studies within Cognitive Genetics Collaborative Research Organization aiming to replicate and extend works of ENIGMA.

Neuroimaging studies within Cognitive Genetics Collaborative Research Organization aiming to replicate and extend works of ENIGMA.

Publication date: Jun 05, 2020

Reproducibility is one of the most important issues for generalizing the results of clinical research; however, low reproducibility in neuroimaging studies is well known. To overcome this problem, the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium, an international neuroimaging consortium, established standard protocols for imaging analysis and employs either meta- and mega-analyses of psychiatric disorders with large sample sizes. The Cognitive Genetics Collaborative Research Organization (COCORO) in Japan promotes neurobiological studies in psychiatry and has successfully replicated and extended works of ENIGMA especially for neuroimaging studies. For example, (a) the ENIGMA consortium showed subcortical regional volume alterations in patients with schizophrenia (n = 2,028) compared to controls (n = 2,540) across 15 cohorts using meta-analysis. COCORO replicated the volumetric changes in patients with schizophrenia (n = 884) compared to controls (n = 1,680) using the ENIGMA imaging analysis protocol and mega-analysis. Furthermore, a schizophrenia-specific leftward asymmetry for the pallidum volume was demonstrated; and (b) the ENIGMA consortium identified white matter microstructural alterations in patients with schizophrenia (n = 1,963) compared to controls (n = 2,359) across 29 cohorts. Using the ENIGMA protocol, a study from COCORO showed similar results in patients with schizophrenia (n = 696) compared to controls (n = 1,506) from 12 sites using mega-analysis. Moreover, the COCORO study found that schizophrenia, bipolar disorder (n = 211) and autism spectrum disorder (n = 126), but not major depressive disorder (n = 398), share similar white matter microstructural alterations, compared to controls. Further replication and harmonization of the ENIGMA consortium and COCORO will contribute to the generalization of their research findings.

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Concepts Keywords
Autism Spectrum Disorder Biological psychiatry
Bipolar Disorder Schizophrenia
Japan Psychosis
Major Depressive Disorder Psychopathology
Meta Analysis Abnormal psychology
Neurobiological Psychiatry
Neuroimaging Disorders
Pallidum Volumetric schizophrenia
Protocol Major depressive disorder
Psychiatric Disorders Schizophrenia bipolar disorder
Psychiatry Similar schizophrenia
Reproducibility Autism spectrum disorder
Schizophrenia Protocols imaging
White Matter Magnetic resonance imaging
Mood disorders
Heather Whalley
Magnetic resonance imaging


Type Source Name
disease MESH psychiatric disorders
disease MESH schizophrenia
disease MESH bipolar disorder
disease MESH autism spectrum disorder
disease MESH major depressive disorder

Original Article

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