A shred of evidence that BCG vaccine may protect against COVID-19: Comparing cohorts in Spain and Italy

A shred of evidence that BCG vaccine may protect against COVID-19: Comparing cohorts in Spain and Italy

Publication date: Jun 06, 2020

Introduction: There is evidence that the BCG vaccine against tuberculosis also helps prevent other diseases- perhaps including COVD-19. Spain had a program for universal BCG vaccination until 1981. Objective: To see whether cohorts born when Spain had a program of universal BCG vaccination had lower rates of confirmed cases of COVID-19 and mortality (relative to similar cohorts in Italy). Methods: We compare COVID-19 mortality and confirmed cases for those born roughly a decade before and after 1981. We compare the outcomes to the same age cohorts in Italy, which never had universal BCG vaccination. Results: The Spanish cohort that received BCG had a relative risk of 0.962 of having a confirmed case of COVID-19. This risk is statistically significantly below unity (95% CI 0.952 to 0.972, PPDF

Concepts Keywords
Aman Verma Vaccinations
Bacillus Vaccination
BCG Immunizations
Bcg Vaccine Immunization
BCG Vaccine Diseases tuberculosis
Berkeley Death communicable diseases
Bmj Related infectious diseases
BMJ 1960s rates tuberculosis
California Risk diseases
China TB
Cohort Counts illness
Communicable Diseases Higher infection
Comorbidities Lower infections 40s
COPD Immunization control
Coronavirus Regions protocols
Cross Risk groups
Diabetes Younger
DTP Medical specialties
EMBO Medicine
Epidemiological Infectious diseases
Europe Tuberculosis vaccines
Globe RTT
Hospital BCG vaccine
Hypertension Vaccination policy
Immune System Html
Immunity Pdf
Incidence Regions protocols
Innate Immune System
Italy
Measles
Morbidity
Mortality
Mortality Rate
Ncbi
Nih
Nlm
Nytimes
Obesity
Outline
Overweight
Pediatrics
Por
Prince Charles
Public Sector
Relative Risk
Resemble
Respiratory Infection
SARS
Spain
Spanish
Systematic Review
Thomson Reuters
Tuberculosis
Vaccination
Vaccine
Wuhan

Semantics

Type Source Name
drug DRUGBANK BCG vaccine
disease MESH tuberculosis
pathway KEGG Tuberculosis
drug DRUGBANK Tropicamide
disease MESH measles
pathway KEGG Measles
disease MESH infection
disease MESH obesity
drug DRUGBANK Ademetionine
drug DRUGBANK Coenzyme M
disease MESH death
disease MESH communicable diseases
disease MESH Overweight
disease MESH cancer
disease MESH COPD
disease MESH hypertension
disease MESH Community
disease MESH Comorbidity
drug DRUGBANK Aminosalicylic Acid
disease MESH diagnosis
drug DRUGBANK Nonoxynol-9
disease MESH Men
disease MESH growth
drug DRUGBANK Pentaerythritol tetranitrate
disease MESH risk factors

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