The role of hippocampal theta oscillations in working memory impairment in multiple sclerosis

The role of hippocampal theta oscillations in working memory impairment in multiple sclerosis

Publication date: Jun 15, 2020

Working memory (WM) problems are frequent in persons with multiple sclerosis (MS). Even though hippocampal damage has been repeatedly shown to play an important role, the underlying neurophysiological mechanisms remain unclear. This study aimed to investigate the neurophysiological underpinnings of WM impairment in MS using magnetoencephalography (MEG) data from a verbal n-back task. We analysed MEG recordings of 79 MS patients and 38 healthy subjects through event-related fields (ERFs) and theta (4-8 Hz) and alpha (8-13 Hz) oscillatory processes. Data was source reconstructed and parcellated based on previous findings in the healthy subject sample. MS patients showed a smaller maximum theta power increase in the right hippocampus between 0 and 400 ms than healthy subjects (p = 0.014). This theta power increase value correlated strongly and negatively with reaction time on the task in MS (r = -0.32, p = 0.029). Evidence was provided that this relationship could not be explained by a confounding relationship with MS-related neuronal damage. This study provides the first neurophysiological evidence of the influence of hippocampal dysfunction on WM performance in MS.

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Concepts Keywords
Amplitude Score processing speed
Atrophy Pre processing projection
Belgium Movements pre processing
Benzodiazepine Precuneus
Benzodiazepines Middle frontal theta
Brain Frontal orbital theta
Brussels Disorder processing speed
CIS Brain
Cognitive Impairment Branches of biology
Cognitive Training Neuroscience
Corticosteroid Gyri
Demyelination Neurophysiology
EEG Electrophysiology
Electroencephalography Limbic system
Epilepsy Hippocampus
Episodic Memory Parahippocampal gyrus
ERP Electroencephalography
Ethics Precuneus
ETRO Alpha
Excitatory Neuroscience
FMRI MRI
Frequency Magnetic resonance imaging
Frequency Band
Functional MRI
Fusiform Gyrus
Gyri
Helmet
Heterogeneity
Hippocampal
Hippocampi
Hippocampus
Hulst
Hz
Inferior Temporal Gyrus
Informed Consent
IQR
Kawasaki
Latency
Libre
Magnetoencephalography
MEG
Memory
Middle School
Multiple Sclerosis
Neural Firing
Neurodegeneration
Neuroimaging
Neurology
Neurophysiological
Occipital
Orbitofrontal Cortex
Oxford
P300
Pacemaker
Paradigm
Parahippocampal Gyrus
Parietal
Piper
Prefrontal
Prefrontal Cortex
Progressive
Psychiatric Disorders
Quartile
Rad
Radiology
Ranganath
Relapse
ROI
Schubert
Statistical Significance
Stdev
Stimulus
Temporal Resolution
Theta Band
ULB
Vrije Universiteit Brussel
Working Memory

Semantics

Type Source Name
disease MESH multiple sclerosis
disease MESH Cognitive impairment
disease MESH employment status
disease MESH demyelination
drug DRUGBANK Albendazole
disease MESH atrophy
disease MESH visual
disease MESH diagnosis
drug DRUGBANK Aspartame
disease MESH relapse
disease MESH psychiatric disorders
disease MESH epilepsy
disease MESH syndrome
drug DRUGBANK Benzodiazepine
disease MESH separation
drug DRUGBANK Pidolic Acid
drug DRUGBANK Tilmicosin

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