Could an Unrelated Live Attenuated Vaccine Serve as a Preventive Measure To Dampen Septic Inflammation Associated with COVID-19 Infection?

Could an Unrelated Live Attenuated Vaccine Serve as a Preventive Measure To Dampen Septic Inflammation Associated with COVID-19 Infection?

Publication date: Jun 19, 2020

We propose the concept that administration of an unrelated live attenuated vaccine, such as MMR (measles, mumps, rubella), could serve as a preventive measure against the worst sequelae of coronavirus disease 2019 (COVID-19). There is mounting evidence that live attenuated vaccines provide nonspecific protection against lethal infections unrelated to the target pathogen of the vaccine by inducing “trained” nonspecific innate immune cells for improved host responses against subsequent infections. Mortality in COVID-19 cases is strongly associated with progressive lung inflammation and eventual sepsis. Vaccination with MMR in immunocompetent individuals has no contraindications and may be especially effective for health care workers who can easily be exposed to COVID-19. Following the lead of other countries conducting clinical trials with the live attenuated Mycobacterium bovis BCG (BCG) vaccine under a similar concept, a clinical trial with MMR in high-risk populations may provide a “low-risk-high-reward” preventive measure in saving lives during this unprecedented COVID-19 pandemic.

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Concepts Keywords
Attenuated Vaccine Immunology
BCG Vaccines
BCG Vaccine Virology
Clinical Trial Vaccination
Clinical Trials RTT
Coronavirus Drugs
Immunocompetent Medicine
Inflammation Medical specialties
Live Attenuated Vaccines Vaccination
Measles Suppressor sepsis
Mumps Inflammation
Mycobacterium Bovis Infections
Pandemic BCG vaccine
Pathogen Attenuated vaccine
Progressive Immunity
Rubella
Sepsis
Sequelae
Vaccination
Vaccine

Semantics

Type Source Name
disease MESH Inflammation
disease MESH Infection
disease MESH measles
pathway KEGG Measles
disease MESH mumps
disease MESH rubella
disease MESH sequelae
disease MESH lung inflammation
disease MESH sepsis
disease MESH contraindications
drug DRUGBANK BCG vaccine
disease MESH tuberculosis
pathway KEGG Tuberculosis
drug DRUGBANK Coenzyme M
drug DRUGBANK Trestolone
disease MESH viral infections
disease MESH community
disease MESH posture
disease MESH sailors
disease MESH death
disease MESH severe acute respiratory syndrome
disease MESH influenza
disease MESH bacterial pneumonia
disease MESH smallpox
disease MESH chickenpox
disease MESH Allergy
disease MESH Infectious Disease
disease MESH risk factors
disease MESH intra abdominal infections

Original Article

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