A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19.

A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19.

Publication date: Jun 24, 2020

The whole world is facing a tough time these days struggling against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There is not any specific effective drug for this viral infection. Thus, we are trying to treat patients with non-specific drug cocktails. Metformin, as a strong base, a potential regulator of Vacuolar ATPase (V-ATPase) and endosomal Na+/H+ exchangers (eNHEs), additionally a regenerative agent for lung fibrosis, seems to be beneficial for patients in acute, chronic and recovery phases of COVID-19.

Concepts Keywords
ATPase Transmembrane proteins
Coronavirus Animal virology
Endosomal Zoonoses
H+ Coronaviridae
Lung Fibrosis Drugs
Metformin Proteins
SARS Viruses
Strong Base SARS
Viral Infection Transport proteins
Metformin

Semantics

Type Source Name
drug DRUGBANK Metformin
disease MESH viral infection
disease MESH fibrosis

Original Article

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