Publication date: Jun 30, 2020
(a) shows the EEG signal from a fish that hadn’t been treated by anti-epileptic drug (AED) while (b) shows the signal from a fish that had been treated by AED.
Professor Sohee Kim, from the Department of Robotics Engineering at Daegu Gyeongbuk Institute of Science and Technology (DGIST), Korea, has been pioneering developments in EEGs for zebrafish for the past several years.
With the drug delivery and fish fixing units separated, no physical/environmental artifacts interfere with and hamper the EEG recording process and output, thereby simultaneously yielding clear recordings of the biological effects of the drugs on all the fish in the fixing unit.
The EEG readings they then got successfully mapped the changes in the fish’s brain signals during the various degrees of ensuing epileptic attacks, demonstrating that their system could accurately measure the efficacy of this anti-epileptic drug.
Prof. Kim comments, “Using EEG recordings, an accurate and quantifiable measure of brain activity, we expect our system to facilitate the mass screening of drugs for neurological diseases such as sleep disorders, epilepsy, and autism. “
Lee et al, An EEG system to detect brain signals from multiple adult zebrafish, Biosensors and Bioelectronics (2020).