Casting a wider net: New system measures brain activity of several zebrafish concurrently

Casting a wider net: New system measures brain activity of several zebrafish concurrently

Publication date: Jun 30, 2020

(a) shows the EEG signal from a fish that hadn’t been treated by anti-epileptic drug (AED) while (b) shows the signal from a fish that had been treated by AED.

Professor Sohee Kim, from the Department of Robotics Engineering at Daegu Gyeongbuk Institute of Science and Technology (DGIST), Korea, has been pioneering developments in EEGs for zebrafish for the past several years.

With the drug delivery and fish fixing units separated, no physical/environmental artifacts interfere with and hamper the EEG recording process and output, thereby simultaneously yielding clear recordings of the biological effects of the drugs on all the fish in the fixing unit.

The EEG readings they then got successfully mapped the changes in the fish’s brain signals during the various degrees of ensuing epileptic attacks, demonstrating that their system could accurately measure the efficacy of this anti-epileptic drug.

Prof. Kim comments, “Using EEG recordings, an accurate and quantifiable measure of brain activity, we expect our system to facilitate the mass screening of drugs for neurological diseases such as sleep disorders, epilepsy, and autism. “

Lee et al, An EEG system to detect brain signals from multiple adult zebrafish, Biosensors and Bioelectronics (2020).

Concepts Keywords
AED Monitoring
Autism Drug delivery
Bioelectronics Biosensors
Biosensors Drug development
Brain Bioelectronics
Breed Electrodiagnosis
Convulsant Electroencephalography
Daegu Zebrafish
Drug Delivery Neurotechnology
Drug Development Brain–computer interfacing
EEG Electrophysiology
Electroencephalography Neurophysiology
Epilepsy Medicine
Epileptic Branches of biology
Fair Dealing Disorders epilepsy autism
Fish Epilepsy
Gyeongbuk Neurological disorders
Key Change
Korea
Mice
Neurological
Neurological Diseases
Neurological Disorders
Plastic
Recording
Sleep Disorders
South Asia
Tank
Toxicity
Valproic Acid
Zebrafish

Semantics

Type Source Name
disease MESH sleep disorders
drug DRUGBANK Water
disease MESH separated
drug DRUGBANK Spinosad
disease MESH epilepsy
drug DRUGBANK Valproic Acid
disease MESH autism
disease MESH neurological disorders
disease MESH development

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