Clinical outcomes and immunologic characteristics of Covid-19 in people with HIV.

Clinical outcomes and immunologic characteristics of Covid-19 in people with HIV.

Publication date: Jun 30, 2020

We performed a retrospective study of Covid-19 in people with HIV (PWH). PWH with Covid-19 demonstrated severe lymphopenia and decreased CD4+ T cell counts. Levels of inflammatory markers, including C-reactive protein, fibrinogen, D-dimer, interleukin-6, interleukin-8, and TNF-alpha were commonly elevated. In all, 19/72 hospitalized individuals (26.4%) died and 53 (73.6%) recovered. PWH who died had higher levels of inflammatory markers and more severe lymphopenia than those who recovered. These findings suggest that PWH remain at risk for severe manifestations of Covid-19 despite ART and that those with increased markers of inflammation and immune dysregulation are at risk for worse outcomes.

Concepts Keywords
C Reactive Protein SARS
CD4 Inflammatory markers
Dimer Markers inflammation
Fibrinogen HIV
HIV HIV inflammation
Inflammation Medical specialties
Interleukin 6 Medicine
Interleukin 8 Branches of biology
Lymphopenia Immunology
TNF Alpha Cytokines
Animal physiology
Human physiology
Inflammation
Interleukin
C-reactive protein
Alpha

Semantics

Type Source Name
disease MESH lymphopenia
drug DRUGBANK Fibrinogen Human
disease MESH inflammation

Original Article

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