QT Interval Evaluation Associated With Use of Hydroxychloroquine with Combined Use of Azithromycin Among Hospitalized Children Positive for COVID-19.

QT Interval Evaluation Associated With Use of Hydroxychloroquine with Combined Use of Azithromycin Among Hospitalized Children Positive for COVID-19.

Publication date: Jul 20, 2020

Hydroxychloroquine alone or in combination with azithromycin has been increasingly used for patients with COVID-19, in both children and adults. Drugs are generally well tolerated in clinical practice; however, both can cause corrected QT prolongation. We aimed to report our experience of QT interval evaluation associated with the use of hydroxychloroquine with concurrent azithromycin among children testing positive for COVID-19.

Our single-centre; retrospective, study evaluated children with COVID-19 disease admitted to the Pediatric Department at Sancaktepe Training and Research Hospital Istanbul, Turkey from 10 March, 2020 to 10 April, 2020. The data including demographics, clinical symptoms, co-morbid diseases, laboratory, radiological findings as well as electrocardiographs of the patients were obtained from our records. Electrocardiograms were evaluated before, one day after and at the termination of the treatment.

21 patients aged 9 to 18 years were evaluated. The median age was 170 months (range 112-214), 51.1% of them were girls and 48.9% were boys. Their laboratory results did not reveal any abnormalities. None of them needed intensive care. We did not detect QT prolongation during or at the termination of the treatment.

We did not detect QT prolongation during or at the termination of the treatment in our patients due to the fact that they were not severely affected by the disease. Patients were treated in our inpatient clinic and none of them required intensive care. Laboratory results were also insignificant. Furthermore they did not need other medications.

Concepts Keywords
Azithromycin Morbid diseases
Concurrent RTT
Electrocardiographs Chemical compounds
Hydroxychloroquine Health
Intensive Care Chloroarenes
Istanbul Quinolines
Turkey Organic compounds
Hydroxychloroquine
Azithromycin
Coronavirus disease

Semantics

Type Source Name
drug DRUGBANK Hydroxychloroquine
drug DRUGBANK Azithromycin
disease MESH abnormalities

Original Article

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