Elevated Liver Biochemistries in Hospitalized Chinese Patients with Severe COVID-19: Systematic Review and Meta-analysis.

Elevated Liver Biochemistries in Hospitalized Chinese Patients with Severe COVID-19: Systematic Review and Meta-analysis.

Publication date: Jul 21, 2020

Several recent studies have reported an abnormal liver chemistry profile among patients with coronavirus disease 2019 (COVID-19), although its clinical significance remains unknown.

This novel systematic review and meta-analysis identified six studies of 586 patients delineating liver chemistries among patients with severe/critical illness versus mild cases of COVID-19 infection. Patients with severe/critical illness with COVID-19 infection have increased prevalence of coronary artery disease (CAD), cerebrovascular disease, and chronic obstructive pulmonary disease (COPD) as compared to mild cases. A significant association between severe/critical COVID-19 infections with elevations in aspartate aminotransferase (AST) (pooled mean difference [MD], 11.70 U/L; 95% confidence interval [CI], 2.97, 20.43; P = 0.009), elevated total bilirubin (pooled MD, 0.14 mg/dL; 95% CI, 0.06, 0.22; P = 0.0005), and decreased albumin (pooled MD, -0.68 g/L; 95% CI, -0.81, -0.55; P

Comorbidities, including CAD, cerebrovascular disease, and COPD, are more prevalent in hospitalized Chinese patients with severe/critical illness from COVID-19, and these patients are more likely to manifest with abnormal liver chemistries. Further prospective studies are crucial to understand the pathophysiologic mechanisms underlying the hepatic manifestations of the novel COVID-19 infection and its clinical significance.

Concepts Keywords
Alanine Aminotransferase Coronavirus disease
Albumin Medical specialties
ALT Hepatology
Aminotransferase Clinical medicine
Aspartate Medicine
AST Leukocytosis neutrophilia lymphopenia
Bilirubin Severe critical illness
CAD Infections
Cerebrovascular Disease Zoonoses
Chinese Cerebrovascular disease
Confidence Interval Alanine transaminase
Coronary Artery
Lactate Dehydrogenase
Meta Analysis
Statistical Significance


Type Source Name
disease MESH critical illness
disease MESH infection
disease MESH coronary artery disease
disease MESH cerebrovascular disease
disease MESH chronic obstructive pulmonary disease
drug DRUGBANK L-Alanine
disease MESH leukocytosis
disease MESH lymphopenia
drug DRUGBANK Creatinine
drug DRUGBANK Prothrombin

Original Article

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