Computerized cognitive rehabilitation for treatment of cognitive impairment in multiple sclerosis: an explorative study.

Computerized cognitive rehabilitation for treatment of cognitive impairment in multiple sclerosis: an explorative study.

Publication date: Jun 30, 2020

In this explorative study, forty-seven patients with relapsing-remitting multiple sclerosis were randomized to a custom 6-week cognitive rehabilitation intervention (n = 23) using the BrainHQ web-based platform and to a control group condition (n = 24). Cognitive rehabilitation intervention consisted of two 40-minute sessions per week. All patients were tested with the Brief International Cognitive Assessment for Multiple Sclerosis battery, the Stroop Color-Word Test, and the trail making test, while the Beck Depression Inventory – Fast Screen questionnaire was used as a measure of mood and the cognitive reserve index as a measure of cognitive reserve. We used the reliable change index, to calculate clinically meaningful changes of performance, and to discriminate between responders and non-responders of this intervention. Statistically significant improvement of the group receiving treatment was observed mainly on measures of verbal and non-verbal episodic memory and, to a lesser extent, on reading speed, selective attention/response inhibition, and visual attention. Verbal memory and visual attention improvements remained significant after considering the corrected for multiple comparisons level of significance. According to reliable change index scores, 12/23 (52.2%) of patients in the intervention group presented meaningful improvement in at least one measure (Greek Verbal Learning Test: 26%, Brief Visuospatial Memory Test-Revised: 17.4%, Stroop-Words test: 13%). This explorative study provides evidence that, at least in the short term, cognitive rehabilitation may improve the cognitive performance of multiple sclerosis patients.

Concepts Keywords
Battery Improvement
Beck Depression Inventory Multiple sclerosis
Cognitive Cognitive multiple sclerosis
Cognitive Impairment Neuropsychology
Control Group Neuroscience
Episodic Memory Neuropsychological assessment
Greek Nervous system
Multiple Comparisons Cognitive reserve
Multiple Sclerosis Geriatric psychiatry
Questionnaire Neurology
Selective Attention


Type Source Name
disease MESH cognitive impairment
disease MESH multiple sclerosis
disease MESH relapsing-remitting multiple sclerosis
disease MESH Depression
disease MESH visual

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