Association between COVID-19 and cardiovascular disease.

Association between COVID-19 and cardiovascular disease.

Publication date: Aug 01, 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19) has reached a pandemic level. SARS-CoV-2 infects host cells through ACE2 receptors, leading to COVID-19-related pneumonia. The rapid increase in confirmed cases makes the prevention and control of COVID-19 extremely serious. Real-time reverse transcription-PCR (RT-PCR) assays remain the molecular test of choice for the etiologic diagnosis of SARS-CoV-2 infection while radiographic findings (chest computed tomography [CT]) and antibody-based techniques are being introduced as supplemental tools. Novel virus also cause chronic damage to the cardiovascular system, and attention should be given to cardiovascular protection during treatment for COVID-19. Acute cardiac injury determined by elevated high-sensitivity troponin levels is commonly observed in severe cases and is strongly associated with mortality. This review suggests that cardiovascular comorbidities are common in patients with COVID-19 and such patients are at higher risk of morbidity and mortality. The continuation of clinically indicated ACE inhibitor and ARB medications is recommended in COVID-19. We review the basics of coronaviruses, novel molecular targets for the coronaviruses with a focus on COVID-19, along with their effects on the cardiovascular system.

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Concepts Keywords
ACE Inhibitor Coronavirus disease
Antibody Angiotensin-converting enzyme 2
Cardiovascular Bat virome
Cardiovascular Disease COVID-19
Cardiovascular System Nidovirales
Comorbidities Animal diseases
Computed Tomography Respiratory diseases
Coronavirus Zoonoses
Etiologic Sarbecovirus
Infection Pneumonia
Morbidity SARS
Mortality Infection
Pandemic Acute cardiac injury
PCR Tomography
Pneumonia Transplantation
Reverse Transcription


Type Source Name
disease MESH cardiovascular disease
disease MESH pneumonia
disease MESH diagnosis
disease MESH infection
drug DRUGBANK Angiotensin II
disease MESH Comorbidity
disease MESH Heart failure

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