Association of Autism Onset, Epilepsy, and Behavior in a Community of Adults with Autism and Severe Intellectual Disability.

Association of Autism Onset, Epilepsy, and Behavior in a Community of Adults with Autism and Severe Intellectual Disability.

Publication date: Jul 27, 2020

Autism spectrum disorders (ASDs) are hard to characterize due to their clinical heterogeneity. Whether epilepsy and other highly prevalent comorbidities may be related to specific subphenotypes such as regressive ASD (i.e., the onset of symptoms after a period of apparently typical development) is controversial and yet to be determined. Such discrepancies may be related to the fact that age, level of cognitive functioning, and environmental variables are often not taken into account. We considered a sample of 20 subjects (i) between 20 and 55 years of age, (ii) with severe/profound intellectual disability, (iii) living in the same rural context of a farm community. As a primary aim, we tested for the association between epilepsy and regressive ASD. Secondly, we explored differences in behavioral and pharmacological profiles related to the presence of each of these conditions, as worse behavioral profiles have been separately associated with both epilepsy and regressive ASD in previous studies. An initial trend was observed for associations between the presence of epilepsy and regressive ASD (odds ratio: 5.33; 95% CI: 0.62-45.41, p-value: 0.086). Secondly, subjects with either regressive ASD or epilepsy showed worse behavioral profiles (despite the higher pharmacotherapy they received). These preliminary results, which need to be further confirmed, suggest the presence of specific associations of different clinical conditions in subjects with rarely investigated phenotypes.

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Concepts Keywords
Autism Epilepsy
Autism Spectrum Disorders Presence epilepsy
Cognitive Pharmacotherapy
Comorbidities Psychiatric diagnosis
Epilepsy Psychiatry
Heterogeneity Abnormal psychology
Intellectual Disability Learning disabilities
Odds Ratio Health
Pharmacological Pervasive developmental disorders
Pharmacotherapy RTT
Phenotypes Autism spectrum
Sci Intellectual disability
Epilepsy

Semantics

Type Source Name
disease MESH Autism
disease MESH Epilepsy
disease MESH Community
disease MESH Intellectual Disability
disease MESH Autism spectrum disorders
disease MESH development

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