[COVID-19: The Perspective Of Nephrology].

[COVID-19: The Perspective Of Nephrology].

Publication date: Jul 01, 2020

Increasing insight into the clinical phenotype and mechanisms of SARS-CoV-2 infections and COVID-19 has identified damage of the kidneys as a key player in the course of the disease. This manuscript summarizes the current knowledge on direct viral infection of kidney tissue, proteinuria and acute kidney injury in COVID-19, and management of patients on chronic dialysis as well as after kidney transplantation. Direct infection of podocytes and proximal tubular cells by SARS-CoV-2 has been confirmed and results in proteinuria and hematuria at an early stage of COVID-19. In this context, any kidney affection is a predictor of worse outcomes among COVID-19 patients irrespective of the initial presentation and increases the risk of acute kidney injury. Specific therapies for kidney damage and acute kidney injury within COVID-19 that could be generally recommended are currently lacking. Patients on chronic hemodialysis in particular are at risk for contracting SARS-CoV-2 infections as indicated by outbreaks and super-spreading events in hemodialysis facilities. Immunosuppressive therapy after kidney transplantation needs to be adapted upon diagnosis of COVID-19 depending on the severity of the initial presentation.

Concepts Keywords
19 Management Acute kidney injury
Acute Kidney Injury Coronavirus disease
Dialysis Organ failure
Hematuria Membrane technology
Hemodialysis Kidney diseases
Immunosuppressive Therapy Clinical medicine
Infection Medical specialties
Kidney Kidney transplantation
Kidney Transplantation Hemodialysis
Kidneys Immunosuppressive therapy
Manuscript Infections
Nephrology Proteinuria hematuria
Phenotype SARS
Podocytes Proteinuria
Proteinuria Kidney transplantation
Proximal Tubular Dialysis
SARS Transplantation
Viral Infection Dialysis


Type Source Name
disease MESH infections
disease MESH viral infection
disease MESH proteinuria
disease MESH acute kidney injury
disease IDO infection
disease MESH hematuria
disease MESH diagnosis

Original Article

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