Restless legs syndrome, sleep quality, and perceived cognitive impairment in adults with multiple sclerosis.

Restless legs syndrome, sleep quality, and perceived cognitive impairment in adults with multiple sclerosis.

Publication date: Aug 01, 2020

Restless Legs Syndrome (RLS) is a prominent sleep disorder that often worsens sleep quality and perhaps cognitive function in adults with multiple sclerosis (MS). The present study examined the relationships among RLS prevalence and severity, sleep quality, and perceived cognitive impairment in adults with MS.

Participants (N=275) completed the Cambridge-Hopkins Restless Legs Syndrome Questionnaire, the International Restless Legs Syndrome Study Group (IRLS) Scale, the Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ), the Pittsburgh Sleep Quality Index (PSQI), the Patient Determined Disease Steps (PDDS), and a demographic and clinical characteristics questionnaire.

Persons with MS who had RLS (i.e., MS+RLS; n=74) reported significantly worse perceived cognitive impairment compared with those who did not have RLS (n=201; p=0.015). Bivariate correlation analyses within the MS+RLS group indicated that greater RLS severity was significantly associated with more severe perceived cognitive impairment (r=0.274) and sleep quality (r=0.380), and worse perceived cognitive impairment was significantly associated with worse sleep quality (r=0.438). Linear, step-wise regression analyses indicated that RLS severity significantly predicted perceived cognitive impairment (?=0.274), but the inclusion of sleep quality (?=0.391) accounted for the relationship between RLS severity and perceived cognitive impairment (?=0.126).

Our results suggest that sleep impairment may be an intermediary factor in the association between RLS severity and cognitive impairment in persons with MS who present with RLS. The diagnosis and treatment of RLS symptoms and other effectors of sleep quality could improve neuropsychological consequences of MS.

Concepts Keywords
Cambridge RLS
Cognitive Cognitive impairment
Cognitive Impairment MS
Correlation Sleep disorders
Demographic Psychiatric diagnosis
Multiple Sclerosis Organ systems
Neuropsychological RTT
Pittsburgh Restless legs syndrome
Questionnaire Syndromes
Regression Health
Restless Legs Syndrome Nervous system
Sleep Draft:Restless Sleep Disorder
Sleep Disorder

Semantics

Type Source Name
disease MESH Restless legs syndrome
disease MESH sleep
disease MESH cognitive impairment
disease MESH multiple sclerosis
disease MESH sleep disorder
disease MESH diagnosis

Original Article

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