SARS-COV-2 Infection in Kidney Transplant Recipients: a Brazilian Multicenter Study

SARS-COV-2 Infection in Kidney Transplant Recipients: a Brazilian Multicenter Study

Publication date: Jul 31, 2020

COVID-19 is the pandemic disease caused by the SARS-CoV-2 coronavirus. It is a highly contagious viral disease, the condition of which main clinical symptoms are characterized by fever and respiratory symptoms. Evidence indicates to worse outcomes in patients with pre-existing diseases, such as diabetes, arterial hypertension, heart disease, pneumopathies, chronic kidney disease, and immunodeficiencies. Recipients of kidney transplants make prolonged use of immunosuppressive drugs to inhibit the acquired immune response, notably the activity of lymphocytes. Due to this potential to modulate the immune and inflammatory response, it is speculated that the clinical and laboratory condition of COVID-19 in these patients is atypical. Preliminary evidence suggests worse outcomes of COVID-19 in immunosuppressed patients, as carriers of cancer. However, information on kidney transplant recipients is insufficient. So far, only reports of the case are available in the literature with different clinical presentations and outcomes. The aim of this study is, therefore, to characterize the demographics, clinical and laboratory conditions, and the outcomes of COVID-19 in kidney transplant recipients in a national multicenter cohort.

Concepts Keywords
Antibodies Fever
Antigens SARS
Arterial Hypertension Chronic kidney disease
Cancer Loss months infection
Chronic Kidney Disease Immune inflammatory response
Clinical Laboratory Kidney transplants
Cohort Dialysis
Coronavirus Mechanical ventilation
Diabetes Medical specialties
Diagnostic Test Clinical medicine
Dialysis Organ transplantation
Evolution Sarbecovirus
Fever Kidney transplantation
Graft Coronavirus disease
Heart Disease Antibodies
Hospital Dialysis
Immune Response
Immunodeficiencies
Immunosuppressed
Immunosuppressive Drugs
Infection
Inflammatory Response
Kidney
Kidney Transplant
Lymphocytes
Mechanical Ventilation
Organ
Pandemic
SARS
Viral Disease
Viral Load

Semantics

Type Source Name
disease MESH Infection
disease MESH viral disease
disease MESH hypertension
disease MESH heart disease
disease MESH chronic kidney disease
disease MESH cancer
disease MESH viral load

Original Article

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