The autism diagnostic observation schedule: Patterns in individuals with anorexia nervosa.

The autism diagnostic observation schedule: Patterns in individuals with anorexia nervosa.

Publication date: Jul 29, 2020

Studies have used the Autism Diagnostic Observation Schedule (the ADOS-2) in individuals with anorexia nervosa (AN), but the patterns of scores have not been assessed. We examined which subset of the ADOS-2 items best discriminate individuals with AN from healthy controls (HC), and assessed the potential clustering of AN participants based on different profiles of the ADOS-2 item scores.

We combined datasets from two previous studies, and (a) compared mean ranks between young AN participants (N = 118) and HC (N = 42), (ii) replicated the item selection procedure of the existing ADOS-2 algorithm to assess sensitivity of items in the AN group, and (c) applied a two-step clustering analysis in the AN group (N = 149).

AN participants displayed significantly higher mean ranks than HC participants in five of 32 items. All five items are part of the existing ADOS-2 algorithm. We found two clusters of AN participants; one representing normal social behaviour, comprising 68% of the individuals with AN, and one representing less efficient social behaviour, comprising 32% of individuals with AN.

The items comprising the social affective cluster of the existing ADOS-2 algorithm are well suited to assess difficulties with social functioning in individuals with AN.

Concepts Keywords
ADOS Step clustering
Algorithm Abnormal psychology
Anorexia Nervosa Psychiatry
Clustering Psychiatric diagnosis
Human behavior
Pervasive developmental disorders
Communication disorders
Eating disorders
Anorexia nervosa
Autism spectrum
2 algorithm


Type Source Name
disease MESH anorexia nervosa
disease MESH autism spectrum disorder

Original Article

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